Glevo 500 mg tablets 10 (levofloxacin)

Composition

film-coated tablets

1 tablet contains levofloxacin (in the form of hemihydrate) 500 mg

pharmachologic effect

Glevo is an antibacterial drug of the group of fluoroquinolones with a wide spectrum of action.

Levofloxacin blocks DNA gyrase (topoisomerase II) and topoisomerase IV, disrupts supercoiling and cross-linking of DNA breaks, inhibits DNA synthesis, causes profound morphological changes in the cytoplasm, cell wall and membranes of microorganisms.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

    infections of ENT organs (including acute sinusitis);

    infections of the lower respiratory tract (including exacerbation of chronic bronchitis, community-acquired pneumonia);

    uncomplicated and complicated infections of the urinary tract and kidneys (including acute pyelonephritis, prostatitis);

    genital infections;

    infections of the skin and soft tissues (festering atheroma, abscess, furunculosis);

    infections of the abdominal cavity (in combination with drugs acting on the anaerobic microflora).

Contraindications

    epilepsy;

    tendon damage with previous treatment with quinolones;

    pregnancy;

    lactation period (breastfeeding);

    children and adolescents (up to 18 years);

    hypersensitivity to levofloxacin and other fluoroquinolones.

Side effects

On the part of the digestive system: nausea, vomiting, diarrhea (including with blood), indigestion, loss of appetite, abdominal pain, pseudomembranous enterocolitis, increased activity of hepatic transaminases, hyperbilirubinemia, hepatitis, dysbacteriosis.

From the side of the cardiovascular system: lowering blood pressure, vascular collapse, tachycardia, prolongation of the QT interval; extremely rarely - atrial fibrillation.

From the endocrine system: hypoglycemia (increased appetite, increased sweating, trembling, nervousness).

From the side of the central nervous system and peripheral nervous system: headache, dizziness, weakness, drowsiness, insomnia, tremor, anxiety, paresthesia, fear, hallucinations, confusion, depression, movement disorders, epileptic seizures (in predisposed patients).

From the senses: impaired vision, hearing, smell, taste and tactile sensitivity.

Interaction

With simultaneous use of levofloxacin increases T1 / 2 of cyclosporine.

The effect of the drug is reduced by drugs that depress intestinal motility, sucralfate, aluminum / magnesium-containing antacids and iron salts (a break between doses of at least 2 hours is required).

With the simultaneous use of Glevo with NSAIDs, theophylline, convulsive readiness increases.

With the simultaneous use of Glevo with GCS, the risk of tendon rupture increases.

Cimetidine and drugs that block tubular secretion slow down the excretion of levofloxacin.

With the simultaneous use of hypoglycemic drugs with levofloxacin, hypo- and hyperglycemia may develop.

Therefore, strict control of blood glucose levels is necessary.

How to take, course of administration and dosage

Glevo is taken orally, 1 or 2 times a day. The average dose is 250 or 500 mg per day.

Overdose

Symptoms: nausea, erosive lesions of the gastrointestinal mucosa, prolongation of the QT interval, confusion, dizziness, convulsions.

Treatment: carry out symptomatic therapy, dialysis is not effective.

Special Instructions

During treatment, it is necessary to avoid solar and artificial UV radiation in order to avoid damage to the skin (photosensitivity).

Storage conditions

In a dry, dark place, at a temperature not exceeding 25 ° C

Best before date

2 years

Active substance

Levofloxacin