Amoxicillin Dispertab 1000 mg dispersible tablets 20

$28.70
Size chart
Women's clothing size
SizeXSSML
Euro 32/34 36 38 40
USA 0/2 4 6 8
Bust(in) 31-32 33 34 36
Bust(cm) 80.5-82.5 84.5 87 92
Waist(in) 24-25 26 27 29
Waist(cm) 62.5-64.5 66.5 69 74
Hips(in) 34-35 36 37 39
Hips(cm) 87.5-89.5 91.5 94 99
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With your arms relaxed at your sides, measure around the fullest part of your chest.

How To Measure Your Waist

Measure around the narrowest part of your natural waist, generally around the belly button. To ensure a comfortable fit, keep one finger between the measuring tape and your body.

Volume discounts

Quantity Unit discount You Save
2 24% $13.78
3 28% $24.11
4 34% $39.03
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Description
Country
Russia
Active ingredient
Amoxicillin
Dosage
1000 mg.
Composition

Active substance: amoxicillin trihydrate 1148 mg, which corresponds to the content of amoxicillin 1000 mg.

Excipients: hyprolose - 98 mg, crospovidone XL-10 - 67.2 mg, sodium stearyl fumarate - 21 mg, lemon flavor - 10.5 mg, tangerine flavor - 8.4 mg, microcrystalline cellulose - 89% + sodium carmellose - 11% (mixture) - 7 mg, sucralose - 2.8 mg, vanilla flavor - 0.7 mg, microcrystalline cellulose 102 - until a tablet weighing 1400 mg is obtained.

Pharmacological properties

Antibiotic of the group of semi-synthetic penicillins of a wide spectrum of action. It is a 4-hydroxyl analogue of ampicillin. It has a bactericidal effect. Active against aerobic Gram-positive bacteria: Staphylococcus spp. (except for strains producing penicillinase), Streptococcus spp.; aerobic gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Klebsiella spp.

Microorganisms that produce penicillinase are resistant to amoxicillin.

In combination with metronidazole, it is active against Helicobacter pylori. Amoxicillin is believed to inhibit the development of Helicobacter pylori resistance to metronidazole.

There is cross-resistance between amoxicillin and ampicillin.

The spectrum of antibacterial action is expanded with the simultaneous use of amoxicillin and a beta-lactamase inhibitor of clavulanic acid. In this combination, the activity of amoxicillin against Bacteroides spp., Legionella spp., Nocardia spp., Pseudomonas (Burkholderia) pseudomallei is increased. However, Pseudomonas aeruginosa, Serratia marcescens and a host of other Gram-negative bacteria remain resistant.

Pharmacokinetics

When taken orally, amoxicillin is quickly and completely absorbed from the gastrointestinal tract, is not destroyed in the acidic environment of the stomach. C max amoxicillin in the blood plasma is reached after 1-2 h. With an increase in the dose by 2 times, the concentration also increases by 2 times. In the presence of food in the stomach does not reduce overall absorption. With intravenous, intramuscular administration and ingestion in the blood, similar concentrations of amoxicillin are achieved.

The binding of amoxicillin to plasma proteins is about 20%.

It is widely distributed in tissues and body fluids. High concentrations of amoxicillin in the liver have been reported.

T 1/2 from plasma is 1-1.5 h. About 60% of the dose taken orally is excreted unchanged in the urine by glomerular filtration and tubular secretion; at a dose of 250 mg the concentration of amoxicillin in the urine is more than 300 μg / ml. Some amount of amoxicillin is determined in the feces.

In newborns and the elderly T 1/2 may be longer.

In renal failure T 1/2 can be 7-20 hours.

In small quantities, amoxicillin penetrates through the BBB with inflammation of the soft meninges.

Amoxicillin is removed by hemodialysis.

Indications for use

For use in the form of monotherapy and in combination with clavulanic acid: infectious and inflammatory diseases caused by sensitive microorganisms, including bronchitis, pneumonia, sore throat, pyelonephritis, urethritis, gastrointestinal infections, gynecological infections, infectious diseases of the skin and soft tissues, listeriosis, leptospirosis, gonorrhea.

For use in combination with metronidazole: chronic gastritis in the acute phase, peptic ulcer of the stomach and duodenum in the acute phase, associated with Helicobacter pylori.

Contraindications

Infectious mononucleosis, lymphocytic leukemia, severe gastrointestinal infections accompanied by diarrhea or vomiting, respiratory viral infections, allergic diathesis, bronchial asthma, hay fever, hypersensitivity to penicillins and / or cephalosporins.

For use in combination with metronidazole: diseases of the nervous system; hematopoietic disorders, lymphocytic leukemia, infectious mononucleosis; hypersensitivity to nitroimidazole derivatives.

For use in combination with clavulanic acid: indications in the anamnesis of impaired liver function and jaundice associated with the intake of amoxicillin in combination with clavulanic acid.

Use in pregnancy and lactation

Amoxicillin penetrates the placental barrier, in small quantities is excreted in breast milk.

If it is necessary to use amoxicillin during pregnancy, the expected benefits of therapy for the mother and the potential risk to the fetus should be carefully weighed.

Use amoxicillin with caution during lactation (breastfeeding).

Use in case of impaired liver function
Amoxicillin in combination with metronidazole should not be used in liver disease.
Use in renal dysfunction
Patients with impaired renal function, the dose and interval between injections should be adjusted in accordance with the values of QC.
Use in children

Use in children is possible according to the dosage regimen.

Amoxicillin in combination with metronidazole is not recommended for use in patients younger than 18 years.

Special instructions

Use with caution in patients prone to allergic reactions.

Amoxicillin in combination with metronidazole is not recommended for use in patients younger than 18 years; should not be used in liver disease.

Against the background of combination therapy with metronidazole, it is not recommended to drink alcohol.

Drug Interactions

Amoxicillin may reduce the effectiveness of oral contraceptives.

With the simultaneous use of amoxicillin with bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin), synergism is manifested; with bacteriostatic antibiotics (including macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) - antagonism.

Amoxicillin enhances the effect of indirect anticoagulants by suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index.

Amoxicillin reduces the effect of drugs, in the process metabolism of which is formed PABA.

Probenecid, diuretics, allopurinol, phenylbutazone, NSAIDs reduce the tubular secretion of amoxicillin, which may be accompanied by an increase in its concentration in the blood plasma.

Antacids, glucosamine, laxatives, aminoglycosides slow down and reduce, and ascorbic acid increases the absorption of amoxicillin.

With the combined use of amoxicillin and clavulanic acid, the pharmacokinetics of both components do not change.

Dosage and Administration

Individual. For oral administration, a single dose for adults and children over 10 years of age (with a body weight of more than 40 kg) is 250-500 mg, in severe cases of the disease - up to 1 g. For children aged 5-10 years, a single dose is 250 mg; at the age of 2 to 5 years - 125 mg. Interval between doses - 8 h. For children weighing less than 40 kg, the daily dose, depending on the indications and clinical situation, may be 20-100 mg / kg in 2-3 doses.

In the treatment of acute uncomplicated gonorrhea - 3 g once (in combination with probenecid). In patients with impaired renal function with QC 10-40 ml / min, the interval between doses should be increased to 12 hours; with QC less than 10 ml / min, the interval between doses should be 24 hours.

With parenteral use in adults / m - 1 g 2 times / day, iv (with normal kidney function) - 2-12 g / day. Children in / m - 50 mg / kg / day, single dose - 500 mg, frequency of administration - 2 times / day; iv - 100-200 mg / kg / day. Patients with impaired renal function, the dose and interval between injections should be adjusted in accordance with the values of QC.

Side effects

Allergic reactions: urticaria, erythema, angioedema, rhinitis, conjunctivitis; rarely - fever, joint pain, eosinophilia; in isolated cases - anaphylactic shock.

Effects associated with chemotherapeutic action: the development of superinfections is possible (especially in patients with chronic diseases or reduced resistance of the body).

With prolonged use in high doses: dizziness, ataxia, confusion, depression, peripheral neuropathies, convulsions.

Mainly when used in combination with metronidazole: nausea, vomiting, anorexia, diarrhea, constipation, epigastrium pain, glossitis, stomatitis; rarely - hepatitis, pseudomembranous colitis, allergic reactions (urticaria, angioedema), interstitial nephritis, hematopoiesis disorders.

Mainly when used in combination with clavulanic acid: cholestatic jaundice, hepatitis; rarely - erythema multiforme, toxic epidermal necrolysis, exfoliative dermatitis.

Storage conditions

At a temperature not exceeding 25 ° C. Keep out of reach of children.

Shelf life 2 years.

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Product Details

Data sheet

Brand
Avva rus
service_future
otc_08
Dosage form
Dispersible tablets
Dosage
1000 mg
INN
Amoxicillin
Number of tablets
20
INN Russian
Амоксициллин
Russian title
Амоксициллин Диспертаб
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