Doxycycline Solution Tablets 100 mg tablets 10
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Active substance: doxycycline monohydrate 104 mg, which corresponds to the content of doxycycline 100 mg.
Excipients: lactose monohydrate - 140.8 mg, microcrystalline cellulose - 96 mg, low-substituted hyprolose - 29.25 mg, sodium saccharinate - 10 mg, hypromellose - 5.85 mg, magnesium stearate - 3.12 mg, silicon dioxide colloidal - 0.98 mg.
Semi-synthetic antibiotic of the group of tetracyclines of a wide spectrum of action. It has a bacteriostatic effect by suppressing the protein synthesis of pathogens.
Active against aerobic gram-positive bacteria: Staphylococcus spp. (including strains producing penicillinase), Streptococcus spp. (incl. Streptococcus pneumoniae), Bacillus anthracis, Listeria monocytogenes; anaerobic bacteria: Clostridium spp.
Doxycycline is also active against aerobic gram-negative bacteria: Neisseria gonorrhoeae, Escherichia coli, Shigella spp., Salmonella spp., Enterobacter spp., Klebsiella spp., Bordetella pertussis, as well as against Rickettsia spp., Treponema spp., Mycoplasma spp. and Chlamydia spp.
Pseudomonas aeruginosa, Proteus spp., Serratia spp., most strains of Bacteroides fragilis are resistant to doxycycline.
After ingestion, it is quickly and almost completely absorbed from the gastrointestinal tract. Food intake slightly affects the absorption of doxycycline. It is widely distributed in tissues and body fluids. Binding to plasma proteins is 80-95%. T 1/2 is 12-22 h. Excreted in the urine unchanged (40%), but the main part of the dose is excreted unchanged with feces due to secretion Bile.
Indications for use
- Infectious and inflammatory diseases caused by microorganisms sensitive to doxycycline, including infections of the respiratory system and ENT organs;
- gastrointestinal infections;
- purulent infections of the skin and soft tissues (including acne);
- infections of the genitourinary system (including gonorrhea, primary and secondary syphilis);
- typhus, brucellosis, rickettsiosis, osteomyelitis, trachoma, chlamydia.
- children's age up to 8 years (the possibility of the formation of insoluble complexes with calcium in the bone skeleton, enamel and dentin of the teeth),
- hypersensitivity to tetracyclines,
- severe liver failure,
- myasthenia gravis (for intravenous administration).
Use in pregnancy and lactation
Doxycycline is contraindicated for use during pregnancy and lactation. Doxycycline penetrates the placental barrier. It can cause long-term discoloration of teeth, enamel hypoplasia, suppression of fetal skeletal bone growth, as well as the development of fatty infiltration of the liver.
If necessary, use during lactation should stop breastfeeding.
Use in case of impaired liver functionContraindicated in severe liver failure. Doxycycline is used with caution in case of impaired liver function.
Use in renal dysfunctionIn case of impaired renal function, dose adjustment is not required.
Use in childrenDoxycycline is not used in children under 8 years of age, because tetracyclines (including doxycycline) cause long-term discoloration of teeth, enamel hypoplasia and slowing of the longitudinal growth of skeletal bones in this category of patients.
Doxycycline is used with caution in case of impaired liver function. In case of impaired renal function, dose adjustment is not required.
To prevent locally irritating effects (esophagitis, gastritis, gastrointestinal ulceration), it is recommended to take it in the daytime with plenty of fluid, food or milk. In connection with the possible development of photosensitivity, it is necessary to limit insolation during treatment and within 4-5 days after it.
Doxycycline is not used in children under 8 years of age, because tetracyclines (including doxycycline) cause a long-term change in the color of the teeth, enamel hypoplasia and a slowdown in the longitudinal growth of the bones of the skeleton in this category of patients.
A solution of doxycycline for intravenous administration should be used no later than 72 hours after its preparation.
Preparations containing metal ions (antacids, preparations containing iron, magnesium, calcium) form inactive chelates with doxycycline, and therefore it is necessary to avoid their simultaneous appointment.
With simultaneous use with barbiturates, carbamazepine, phenytoin, the concentration of doxycycline in the blood plasma decreases due to the induction of microsomal liver enzymes, which may be the reason for a decrease in its antibacterial effect.
It is necessary to avoid combination with penicillins, cephalosporins, which have a bactericidal effect and are antagonists of bacteriostatic antibiotics (including doxycycline).
Absorption of doxycycline is reduced by colestyramine and colestipol (observe the interval between doses of at least 3 hours).
Due to the suppression of intestinal microflora, doxycycline reduces the prothrombin index, which requires dose adjustment of indirect anticoagulants.
Taking doxycycline reduces the reliability of contraception and increases the frequency of breakthrough bleeding while taking estrogen-containing oral contraceptives.
The simultaneous use of retinol contributes to an increase in intracranial pressure.
Dosage and Administration
Inwards. Tablets are dissolved in a small amount of water (about 20 ml) to obtain a suspension, the tablets can also be swallowed whole, divided into parts or chewed with water. Preferably taken with meals. Take tablets sitting or standing, which reduces the likelihood of developing esophagitis or esophageal ulcers. The drug should not be taken immediately before bedtime. Usually the duration of treatment is 5-10 days.
From the digestive system: nausea, vomiting, anorexia, abdominal pain, diarrhea, constipation, dysphagia, glossitis, esophagitis, transient increase in blood content hepatic transaminases, ALP, bilirubin.
From the hematopoietic system: neutropenia, thrombocytopenia, hemolytic anemia.
Allergic reactions: skin rash, itching, eosinophilia; rarely - Quincke's edema, photosensitivity.
Other: increased residual nitrogen, candidiasis, intestinal dysbiosis, discoloration of teeth in children.
The drug should be stored out of the reach of children at a temperature of 15 ° to 25 ° C.
- Dosage form
- Dispersible tablets
- 100 mg
- Number of tablets
- INN Russian