Levomycetin (Chloramphenicol) Actitab 500 mg tablets 10
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A broad-spectrum bacteriostatic antibiotic disrupts the process of protein synthesis in a microbial cell at the stage of transferring t-RNA amino acids to ribosomes.
Effective against strains of bacteria resistant to penicillin, tetracyclines, sulfonamides.
It is active against the following microorganisms: Escherichia coli, Shigella dysenteriae, Shigellaf Iexneri, Shigella boydii, Shigella sonnei, Salmonella spp (including Salmonella typhi, Salmonella paratyphi), Staphylococcus spp., Streptococcus spp. (including Streptococcus pneumoniae), Neisseria meningitidis, Neisseria gonorrhoeae, a number of strains of Proteus spp., Burkholderia pseudomallei, Rickettsia spp., Treponema spp., Leptospira spp., Chlamydia spp. (including Chlamydia trachomatis), Coxiella burnetii, Ehrlichia canis, Klebsiella pneumoniae, Haemophilus influenzae.
He acts on acid-resistant bacteria (et al. Mycobacterium tuberculosis), anaerobes, methicillin-resistant strains of staphylococci, Acinetobacter spp., Enterobacter spp., Serratia marcescens, indolositive strains of Proteus spp., Pseudomonas aeruginosa, protozoa and fungi. The resistance of microorganisms develops slowly.
Indications for use
- urinary and biliary tract infections caused by sensitive microorganisms.
- inhibition of bone marrow hematopoiesis;
- acute intermittent porphyria;
- deficiency of glucose-6-phosphate dehydrogenase;
- hepatic and / or renal failure;
- skin diseases (psoriasis, eczema, fungal infections);
- lactation period;
- children's age up to 3 years and / or body weight less than 20 kg.
Use with caution in patients who have previously received treatment with cytostatic drugs or radiation therapy.
Use in pregnancy and lactation
Contraindicated in pregnancy and lactation.
Use in case of impaired liver function
Contraindicated in hepatic insufficiency.
Use in renal dysfunctionContraindicated in renal failure.
Use in children
Contraindicated in children under 3 years of age, as well as children weighing less than 20 kg.
Severe complications from the side The hematopoietic system is usually associated with the use of high doses for a long time.
With the simultaneous intake of ethanol, the development of a disulfiram-like reaction (facial flushing, spasm in the abdomen and stomach, nausea, vomiting, headache, lowering blood pressure, tachycardia, shortness of breath) is possible.
Dosage and Administration
Inside (30 minutes before meals, and with the development of nausea and vomiting - 1 hour after eating), 3-4 times / day. A single dose for adults is 0.25-0.5 g, daily dose is 2 g. In severe forms of infections (in a hospital setting), it is possible to increase the dose to 3-4 g / day (under the control of blood, kidney and liver function). Children older than 3 years and / or body weight of more than 20 kg are prescribed 12.5 mg / kg every 6 hours or 25 mg every 12 hours, in severe infections - up to 75-100 mg / kg / day (under the control of the concentration of the drug in the blood serum). The average duration of treatment is 8-10 days.
Symptoms: nausea, vomiting.
Treatment: gastric lavage, symptomatic therapy, hemosorption.
From the digestive system: dyspepsia, nausea, vomiting (the likelihood of development decreases when taken 1 hour after eating), diarrhea, irritation of the oral mucosa and throat, dermatitis, dysbacteriosis (suppression of normal microflora).
From the hematopoietic organs: reticulocytopenia, leukopenia, granulocytopenia, thrombocytopenia, erythrocytopenia; rarely - aplastic anemia, agranulocytosis.
From the nervous system: psychomotor disorders, depression, confusion, peripheral neuritis, optic neuritis, visual and auditory hallucinations, decreased visual and hearing acuity, headache.
Allergic reactions: skin rash, angioedema.
Other: secondary fungal infection.
- Obolensk Pharmaceutical
- Dosage form
- 500 mg
- Number of tablets
- INN Russian
- Russian title
- Левомицетин Актитаб