Pancef (Cefixime) 400 mg tablets 6

$38.50
Size chart
Women's clothing size
SizeXSSML
Euro 32/34 36 38 40
USA 0/2 4 6 8
Bust(in) 31-32 33 34 36
Bust(cm) 80.5-82.5 84.5 87 92
Waist(in) 24-25 26 27 29
Waist(cm) 62.5-64.5 66.5 69 74
Hips(in) 34-35 36 37 39
Hips(cm) 87.5-89.5 91.5 94 99
How To Measure Your Bust

With your arms relaxed at your sides, measure around the fullest part of your chest.

How To Measure Your Waist

Measure around the narrowest part of your natural waist, generally around the belly button. To ensure a comfortable fit, keep one finger between the measuring tape and your body.

Volume discounts

Quantity Unit discount You Save
2 18% $13.86
3 21% $24.26
4 26% $40.04
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Description
Country
Macedonia
Active ingredient
Cefixime
Dosage
400 mg
Composition
Active substance: cefixime 400 mg
Excipients: MCC; pregelatinized starch; calcium dihydrogen phosphate; gelatin; corn starch; sodium lauryl sulfate; magnesium stearate; hypromellose; macrogol 4000; titanium dioxide (E171)
Pharmacological properties

Semi-synthetic cephalosporin antibiotic of the III generation for oral administration of a wide spectrum of action. It acts bactericidal. The mechanism of action is due to inhibition of the synthesis of the cell membrane of the pathogen. Cefixime is resistant to the action of β-lactamases, produced by most gram-positive and gram-negative bacteria.

In vitro, cefixime is active against gram-positive bacteria: Streptococcus agalactiae; Gram-negative bacteria: Haemophilus parainfluenzae, Proteus vulgaris, Klebsiella pneumoniae, Klebsiella oxytoca, Pasteurella multocida, Providencia spp., Salmonella spp., Shigella spp., Citrobacter amalonaticus, Citrobacter diversus, Serratia marcescens.

In vitro and in clinical practice, cefixime is active against gram-positive bacteria: Streptococcus pneumoniae, Streptococcus pyogenes; Gram-negative bacteria: Haemophilus influenzae, Moraxella (Branhamella) catarrhalis, Escherichia coli, Proteus mirabilis, Neisseria gonorrhoeae.

Pseudomonas spp., Enterococcus (Streptococcus) of serogroup D, Listeria monocytogenes, most Staphylococcus spp. are resistant to cefixime. (including methicillin-resistant strains), Enterobacter spp., Bacteroides fragilis, Clostridium spp.

Indications for use

Infectious and inflammatory diseases caused by sensitive to cefixime by microorganisms:

  • upper respiratory tract infections (tonsillitis, pharyngitis, sinusitis);

  • otitis media;

  • lower respiratory tract infections (bronchitis, tracheobronchitis);

  • urinary tract infections;

  • uncomplicated gonorrhea (urethra and cervix).

Contraindications

Hypersensitivity to cephalosporins and penicillins.

Use in pregnancy and lactation

Use during pregnancy is possible only when the intended benefit to the mother exceeds the potential risk to the fetus.

If necessary, use during lactation should be discontinued thoracic Feeding.

Use in renal dysfunction

In case of impaired renal function (with QC from 21 to 60 ml / min) or in patients on hemodialysis, the daily dose should be reduced by 25%. With QC≤20 ml / min, the daily dose should be reduced by 2 times.

Use in children
With caution should be used in children under the age of 6 months.
Use in elderly patients
With caution should be used in elderly patients.
Special instructions

With caution should be used in elderly patients, patients with chronic renal failure or pseudomembranous colitis (in the anamnesis), in children under the age of 6 months.

With prolonged use, a violation of the normal intestinal microflora is possible, which can lead to the growth of Clostridium difficile and cause the development of severe diarrhea and pseudomembranous colitis.

In patients with an indication in the anamnesis of allergic reactions to penicillins, manifestations of hypersensitivity to cephalosporin antibiotics are possible.

During treatment, a positive direct Coombs reaction and a false-positive urine reaction to glucose are possible.

Dosage and Administration

For adults and children over 12 years of age with a body weight of more than 50 kg, the daily dose is 400 mg (1 time / day or 200 mg 2 times / day). The duration of the course of treatment is 7-10 days. With uncomplicated gonorrhea - 400 mg once.

Children under the age of 12 years - 8 mg / kg body weight 1 time / day or 4 mg / kg every 12 hours.

For infections caused by Streptococcus pyogenes, the course of treatment should be at least 10 days.

In case of impaired renal function (with QC from 21 to 60 ml / min) or in patients on hemodialysis, the daily dose should be reduced by 25%.

With QC≤20 ml / min or in patients on peritoneal dialysis, the daily dose should be reduced by 2 times.

Overdose

Blockers of tubular secretion (allopurinol, diuretics) delay the excretion of cefixime by the kidneys, which can lead to increased toxicity.

Cefixime reduces the prothrombin index, enhances the effect of indirect anticoagulants.

Antacids containing magnesium or aluminum hydroxide slow down the absorption of cefixime.

Side effects

From the digestive system: dry mouth, anorexia, diarrhea, nausea, vomiting, abdominal pain, flatulence, transient increase in the activity of hepatic transaminases and ALP, hyperbilirubinemia, jaundice, candidiasis of the gastrointestinal tract, dysbacteriosis; rarely - stomatitis, glossitis, pseudomembranous enterocolitis.

From the hematopoietic system: leukopenia, thrombocytopenia, neutropenia, hemolytic anemia.

From the side of the central nervous system: dizziness, headache.

From the urinary system: interstitial nephritis.

Allergic reactions: skin itching, urticaria, skin flushing, eosinophilia, fever.

Storage conditions
In a dark place, at a temperature not exceeding 25 ° C.
Shelf life 3 years.
Pharmacological properties

Semi-synthetic cephalosporin antibiotic of the III generation for oral administration of a wide spectrum of action. It acts bactericidal. The mechanism of action is due to inhibition of the synthesis of the cell membrane of the pathogen. Cefixime is resistant to the action of β-lactamases, produced by most gram-positive and gram-negative bacteria.

In vitro, cefixime is active against gram-positive bacteria: Streptococcus agalactiae; Gram-negative bacteria: Haemophilus parainfluenzae, Proteus vulgaris, Klebsiella pneumoniae, Klebsiella oxytoca, Pasteurella multocida, Providencia spp., Salmonella spp., Shigella spp., Citrobacter amalonaticus, Citrobacter diversus, Serratia marcescens.

In vitro and in clinical practice, cefixime is active against gram-positive bacteria: Streptococcus pneumoniae, Streptococcus pyogenes; Gram-negative bacteria: Haemophilus influenzae, Moraxella (Branhamella) catarrhalis, Escherichia coli, Proteus mirabilis, Neisseria gonorrhoeae.

Pseudomonas spp., Enterococcus (Streptococcus) of serogroup D, Listeria monocytogenes, most Staphylococcus spp. are resistant to cefixime. (including methicillin-resistant strains), Enterobacter spp., Bacteroides fragilis, Clostridium spp.

Indications for use

Infectious and inflammatory diseases caused by sensitive to cefixime Microorganisms:

  • upper respiratory tract infections (tonsillitis, pharyngitis, sinusitis);

  • otitis media;

  • lower respiratory tract infections (bronchitis, tracheobronchitis);

  • urinary tract infections;

  • uncomplicated gonorrhea (urethra and cervix).

Contraindications

Hypersensitivity to cephalosporins and penicillins.

Use in pregnancy and lactation

Use during pregnancy is possible only when the intended benefit to the mother exceeds the potential risk to the fetus.

If necessary, use during lactation should stop breastfeeding.

Use in renal dysfunction

In case of impaired renal function (with QC from 21 to 60 ml / min) or in patients on hemodialysis, the daily dose should be reduced by 25%. With QC≤20 ml / min, the daily dose should be reduced by 2 times.

Use in children
With caution should be used in children under the age of 6 months.
Use in elderly patients
With caution should be used in elderly patients.
Special instructions

With caution should be used in elderly patients, patients with chronic renal failure or pseudomembranous colitis (in the anamnesis), in children under the age of 6 months.

With prolonged use, a violation of the normal intestinal microflora is possible, which can lead to the growth of Clostridium difficile and cause the development of severe diarrhea and pseudomembranous colitis.

In patients with a history of allergic reactions to penicillins, possible manifestations of hypersensitivity to cephalosporin antibiotics.

During treatment, a positive direct Coombs reaction and a false-positive urine reaction to glucose are possible.

Dosage and Administration

For adults and children over 12 years of age with a body weight of more than 50 kg, the daily dose is 400 mg (1 time / day or 200 mg 2 times / day). The duration of the course of treatment is 7-10 days. With uncomplicated gonorrhea - 400 mg once.

Children under the age of 12 years - 8 mg / kg body weight 1 time / day or 4 mg / kg every 12 hours.

For infections caused by Streptococcus pyogenes, the course of treatment should be at least 10 days.

In case of impaired renal function (with QC from 21 to 60 ml / min) or in patients on hemodialysis, the daily dose should be reduced by 25%.

With QC≤20 ml / min or in patients on peritoneal dialysis, the daily dose should be reduced by 2 times.

Overdose

Blockers of tubular secretion (allopurinol, diuretics) delay the excretion of cefixime by the kidneys, which can lead to increased toxicity.

Cefixime reduces the prothrombin index, enhances the effect of indirect anticoagulants.

Antacids containing magnesium or aluminum hydroxide slow down the absorption of cefixime.

Side effects

From the digestive system: dry mouth, anorexia, diarrhea, nausea, vomiting, abdominal pain, flatulence, transient increase in the activity of hepatic transaminases and ALP, hyperbilirubinemia, jaundice, candidiasis of the gastrointestinal tract, dysbacteriosis; rarely - stomatitis, glossitis, pseudomembranous enterocolitis.

From the hematopoietic system: leukopenia, thrombocytopenia, neutropenia, hemolytic anemia.

From the side of the central nervous system: dizziness, headache.

From the urinary system: interstitial jade.

Allergic reactions: skin itching, urticaria, skin flushing, eosinophilia, fever.

Storage conditions
In a dark place, at a temperature not exceeding 25 ° C.
Shelf life 3 years.
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Product Details

Data sheet

Brand
Alkaloid
service_future
otc_15
Dosage form
Tablets
Dosage
400 mg
INN
Cefixime
Number of tablets
6
INN Russian
Цефиксим
Russian title
Панцеф
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