Sumamed 250 mg capsules 6

$28.70
Size chart
Women's clothing size
SizeXSSML
Euro 32/34 36 38 40
USA 0/2 4 6 8
Bust(in) 31-32 33 34 36
Bust(cm) 80.5-82.5 84.5 87 92
Waist(in) 24-25 26 27 29
Waist(cm) 62.5-64.5 66.5 69 74
Hips(in) 34-35 36 37 39
Hips(cm) 87.5-89.5 91.5 94 99
How To Measure Your Bust

With your arms relaxed at your sides, measure around the fullest part of your chest.

How To Measure Your Waist

Measure around the narrowest part of your natural waist, generally around the belly button. To ensure a comfortable fit, keep one finger between the measuring tape and your body.

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2 24% $13.78
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4 34% $39.03
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Description
Country
Croatia
Active ingredient
Azithromycin
Dosage
250 mg
Composition
Active substance: azithromycin dihydrate 262.05 mg, which corresponds to the content of azithromycin 250 mg

Excipients: microcrystalline cellulose - 43.95 mg, sodium lauryl sulfate - 1.4 mg, magnesium stearate - 12.6 mg.

Composition of solid gelatin capsule No1*: (gelatin - q.s., titanium dioxide (E171) - q.s., indigo carmine - q.s.) - 75 mg.

Pharmacological properties

Bacteriostatic antibiotic of the group of macrolides-azalides. It has a wide spectrum of antimicrobial action. The mechanism of action of azithromycin is associated with the suppression of protein synthesis of the microbial cell. Binding to the 50S-subunit of the ribosome, inhibits peptide translocase at the translation stage and inhibits the synthesis protein, slowing down the growth and reproduction of bacteria. In high concentrations, it has a bactericidal effect.

It has activity against a number of gram-positive, gram-negative, anaerobes, intracellular and other microorganisms.

Microorganisms may initially be resistant to the action of the antibiotic or may acquire resistance to it.

Indications for use

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

  • infections of the upper respiratory tract and ENT organs (pharyngitis / tonsillitis, sinusitis, otitis media);
  • infections of the lower respiratory tract (acute bronchitis, exacerbation of chronic bronchitis, pneumonia, incl. caused by atypical pathogens);
  • infections of the skin and soft tissues (erysipelas, impetigo, secondary infected dermatoses, acne vulgaris of moderate severity (for tablets));
  • the initial stage of Lyme disease (borreliosis) - erythema migrans (erythema migrans);
  • urinary tract infections (urethritis, cervicitis) caused by Chlamydia trachomatis (for tablets and capsules).
Contraindications
  • hypersensitivity to azithromycin, erythromycin, other macrolides or ketolids, or other components of the drug;
  • severe liver dysfunction;
  • simultaneous administration with ergotamine and dihydroergotamine;
  • children's age up to 12 years with a body weight of <45 kg (for capsules and tablets of 500 mg);
  • children's age up to 3 years (for tablets of 125 mg);
  • children's age up to 6 months (for powder for the preparation of suspension);
  • deficiency of sucrase / isomaltase, fructose intolerance, glucose- galactose malabsorption (for powder for suspension preparation).

With caution: myasthenia gravis; violations of liver function of mild and moderate severity; terminal renal failure with GFR less than 10 ml / min; in patients with the presence of proarrhythmogenic factors (especially in old age) - with congenital or acquired prolongation of the QT interval, in patients receiving therapy with antiarrhythmic drugs of classes IA (quinidine, procainamide) and III (dofetilide, amiodarone and sotalol), cisapride, terfenadine, antipsychotic drugs (pimozide), antidepressants (citalopram), fluoroquinolones (moxifloxacin and levofloxacin), with impaired water-electrolyte balance, especially with hypokalemia or hypomagnesemia, with clinically significant bradycardia, arrhythmia or with severe heart failure; with the simultaneous use of digoxin, warfarin, cyclosporine; diabetes mellitus (for powder for the preparation of suspension).

Application during pregnancy and lactation

During pregnancy and during breastfeeding, the use of the drug is possible only if the expected potential benefit of therapy for the mother exceeds the potential risk to the fetus and child.

If it is necessary to use the drug during lactation, breastfeeding should be suspended.

Use in case of impaired liver function
In severe violations of liver function (class C on the Child-Pugh scale), the drug is contraindicated. With caution should be prescribed for mild and moderate impairment of liver function.
Use in renal dysfunction
In severe renal dysfunction (QC <40 ml / min), the drug is contraindicated. With caution, the drug should be prescribed for mild and moderate renal impairment.
Use in children

Contraindicated: children under 12 years of age and body weight less than 45 kg (for capsules and tablets of 500 mg); children's age up to 3 years (for tablets of 125 mg; children's age up to 6 months (for powder for the preparation of suspension).

Use in elderly patients
In elderly patients, dose adjustment of Sumamed ® not required. Since this category of patients may have proarrhythmogenic conditions, Sumamed should be used with caution. ® due to the high risk of developing arrhythmias, incl. ventricular arrhythmia of the "pirouette" type.
Special instructions

In case of missing one dose of the drug - the missed dose should be taken as early as possible, and subsequent - with interruptions of 24 hours.

Drug Sumamed ® should be taken at least 1 hour before or 2 hours after taking antacid drugs.

Drug Sumamed ® should use with caution in patients with impaired liver function of mild and moderate severity due to the possibility of developing fulminant hepatitis and severe hepatic insufficiency. In the presence of symptoms of impaired liver function, such as rapidly increasing asthenia, jaundice, darkening of urine, a tendency to bleeding, hepatic encephalopathy, therapy with Sumamed ® a study of the functional state of the liver should be discontinued and conducted.

In case of impaired renal function in patients with GFR 10-80 ml / min, dose adjustment is not required, therapy with Sumamed ® should be carried out with caution under the control of the state of kidney function.

As with the use of other antibacterial drugs, with therapy with Sumamed ® patients should be regularly examined for the presence of immune microorganisms and signs of the development of superinfections, in including fungal.

Drug Sumamed ® should not be used in longer courses than indicated in the instructions, because pharmacokinetic properties of azithromycin allow us to recommend a short and simple dosing regimen.

There is no data on the possible interaction between azithromycin and derivatives of ergotamine and dihydroergotamine, but due to the development of ergotism with the simultaneous use of macrolides with derivatives of ergotamine and dihydroergotamine, this combination is not recommended.

With prolonged use of the drug Sumamed ® pseudomembranous colitis caused by Clostridium difficile may develop, both in the form of mild diarrhea and severe colitis. With the development of antibiotic-associated diarrhea while taking the drug Sumamed ® , as well as 2 months after the end of therapy, clostridial pseudomembranous colitis should be excluded. Do not use drugs that inhibit intestinal motility.

During treatment with macrolides, including azithromycin, there was an elongation of cardiac repolarization and the QT interval, which increase the risk of developing cardiac arrhythmias, including arrhythmias of the "pirouette" type.

Caution should be exercised when using sumamed ® in patients with the presence of proarrhythmogenic factors (especially in elderly patients), incl. with congenital or acquired prolongation of the QT interval; in patients,
taking antiarrhythmic drugs of classes IA (quinidine, procainamide), III (dofetilide, amiodarone and sotalol), cisapride, terfenadine, antipsychotic drugs (pimozide), antidepressants (citalopram), fluoroquinolones (moxifloxacin and levofloxacin), in patients with impaired water-electrolyte balance, especially in the case of hypokalemia or hypomagnesemia, clinically significant bradycardia, cardiac arrhythmia or severe heart failure.

Application of Sumamed ® can provoke the development of myasthenic syndrome or cause an exacerbation of myasthenia gravis.

When used in patients with diabetes mellitus, as well as in patients following a low-calorie diet, it must be borne in mind that the composition of the powder for the preparation of Suspension Sumamed ® sucrose (0.32 XE/5 ml) is included as an excipient.

Influence on the ability to drive vehicles and control mechanisms

With the development of undesirable effects from the nervous system and the organ of vision, caution should be exercised when performing actions that require increased concentration of attention and speed of psychomotor reactions.

Dosage and Administration

The drug is prescribed orally 1 time per day. Capsules are taken at least 1 hour before or 2 hours after meals.

Children 6 months and older are recommended to use the drug in the form of a suspension for oral administration or tablets of 125 mg

For infections of the upper and lower respiratory tract, skin and soft tissues (with the exception of chronic erythema migrans), adults are prescribed the drug at a dose of 500 mg 1 time / day for 3 days, the course dose is 1.5 g.
Children are prescribed at the rate of 10 mg / kg body weight 1 time / day for 3 days, the course dose is 30 mg / kg.

In chronic erythema migrans:
adults are prescribed the drug 1 time / day for 5 days: 1 day - 1 g (2 tab. 500 mg each), then from 2 to 5 days - 500 mg, the course dose is 3 g.
Children are prescribed at 1 day at a dose of 20 mg / kg body weight and then from 2 to 5 days - daily at a dose of 10 mg / kg body weight, the course dose is 60 mg / kg.

Overdose

Symptoms: nausea, temporary hearing loss, vomiting, diarrhea.

Treatment: symptomatic therapy.

Side effects

The frequency of side effects is classified according to WHO recommendations: very often (≥10%), often (≥1% -<10%), infrequently (≥0.1% -<1%), rarely (≥0.01% - <0.1%), very rarely (<0.01%), unknown frequency (cannot be estimated on the basis of available data).

Infectious diseases: infrequently - candidiasis (including oral mucosa and genitals), pneumonia, pharyngitis, gastroenteritis, respiratory diseases, rhinitis; unknown frequency - pseudomembranous colitis.

From the blood and lymphatic system: infrequently - leukopenia, neutropenia, eosinophilia; very rarely - thrombocytopenia, hemolytic anemia.

From the side of metabolism: infrequently - anorexia.

Allergic reactions: infrequently - angioedema, hypersensitivity reaction; unknown frequency - anaphylactic reaction.

From the nervous system: often - headache; infrequently - dizziness, impaired taste, paresthesia, drowsiness, insomnia, nervousness; rarely - agitation; unknown frequency - hypoesthesia, anxiety, aggression, fainting, convulsions, psychomotor hyperactivity, loss of smell, perversion of the sense of smell, loss of taste, myasthenia gravis, delusions, hallucinations.

From the side of the organ of vision: infrequently - visual impairment.

From the side of the organ of hearing and labyrinth disorders: infrequently - hearing disorder, vertigo; unknown frequency - hearing impairment up to deafness and / or tinnitus.

From the cardiovascular system: infrequently - a feeling of palpitations, flushes of blood to the face; unknown frequency - a decrease in blood pressure, an increase in the QT interval on the ECG, arrhythmia of the "pirouette" type, ventricular tachycardia.

From the respiratory system: infrequently - shortness of breath, nosebleeds.

From the gastrointestinal tract: very often - diarrhea; often - nausea, vomiting, abdominal pain; infrequently - flatulence, dyspepsia, constipation, gastritis, dysphagia, bloating, dryness of the oral mucosa, belching, ulcers of the oral mucosa, increased secretion of salivary glands; very rarely - a change in the color of the tongue, pancreatitis.

From the liver and biliary tract: infrequently - hepatitis; rarely - impaired liver function, cholestatic jaundice; unknown frequency - liver failure (in rare cases with a fatal outcome mainly against the background of severe impairment of liver function), liver necrosis, fulminant hepatitis.

From the skin and subcutaneous tissues: infrequently - skin rash, itching, urticaria, dermatitis, dry skin, sweating; rarely - photosensitization reaction; unknown frequency - Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme.

From the musculoskeletal system: infrequently - osteoarthritis, myalgia, pain in back, neck pain; unknown frequency - arthralgia.

From the kidneys and urinary tract: infrequently - dysuria, pain in the kidney area; unknown frequency - interstitial nephritis, acute renal failure.

From the genitals and mammary gland: infrequently - metrorrhagia, impaired testicular function.

Other: infrequently - asthenia, malaise, fatigue, swelling of the face, chest pain, fever, peripheral edema.

Storage conditions
The drug should be stored out of the reach of children at a temperature not exceeding 25 ° C.
Shelf life 3 years.
Indications for use

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

  • infections of the upper respiratory tract and ENT organs (pharyngitis / tonsillitis, sinusitis, otitis media);
  • infections of the lower respiratory tract (acute bronchitis, exacerbation of chronic bronchitis, pneumonia, incl. caused by atypical pathogens);
  • infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses, acne vulgaris of moderate severity (for tablets));
  • the initial stage of Lyme disease (borreliosis) - erythema migrans (erythema migrans);
  • urinary tract infections (urethritis, cervicitis) caused by Chlamydia trachomatis (for tablets and capsules).
Contraindications
  • hypersensitivity to azithromycin, erythromycin, other macrolides or ketolids, or other components of the drug;
  • severe liver dysfunction;
  • simultaneous administration with ergotamine and dihydroergotamine;
  • children's age up to 12 years with a body weight of <45 kg (for capsules and tablets of 500 mg);
  • children's age up to 3 years (for tablets of 125 mg);
  • children's age up to 6 months (for powder for the preparation of suspension);
  • deficiency of sucrase / isomaltase, fructose intolerance, glucose-galactose malabsorption (for powder for suspension preparation).

With caution: myasthenia gravis; impaired liver function mild and moderate severity; terminal renal failure with GFR less than 10 ml / min; in patients with the presence of proarrhythmogenic factors (especially in old age) - with congenital or acquired prolongation of the QT interval, in patients receiving therapy with antiarrhythmic drugs of classes IA (quinidine, procainamide) and III (dofetilide, amiodarone and sotalol), cisapride, terfenadine, antipsychotic drugs (pimozide), antidepressants (citalopram), fluoroquinolones (moxifloxacin and levofloxacin), with impaired water-electrolyte balance, especially with hypokalemia or hypomagnesemia, with clinically significant bradycardia, arrhythmia or with severe heart failure; with the simultaneous use of digoxin, warfarin, cyclosporine; diabetes mellitus (for powder for the preparation of suspension).

Use in pregnancy and lactation

During pregnancy and during breastfeeding, the use of the drug is possible only if if the expected potential benefit of therapy to the mother outweighs the potential risk to the fetus and baby.

If it is necessary to use the drug during lactation, breastfeeding should be suspended.

Use in case of impaired liver function
In severe violations of liver function (class C on the Child-Pugh scale), the drug is contraindicated. With caution should be prescribed for mild and moderate impairment of liver function.
Use in renal dysfunction
In severe renal dysfunction (QC <40 ml / min), the drug is contraindicated. With caution, the drug should be prescribed for mild and moderate renal impairment.
Use in children

Contraindicated: children under 12 years of age and body weight less than 45 kg (for capsules and tablets of 500 mg); children's age up to 3 years (for tablets of 125 mg; children's age up to 6 months (for powder for the preparation of suspension).

Use in elderly patients
In elderly patients, dose adjustment of Sumamed ® not required. Since this category of patients may have proarrhythmogenic conditions, Sumamed should be used with caution. ® due to the high risk of developing arrhythmias, incl. ventricular arrhythmia of the "pirouette" type.
Dosage and Administration

The drug is prescribed orally 1 time per day. Capsules are taken at least 1 hour before or 2 hours after meals.

Children 6 months and older are recommended to use the drug in the form of a suspension for oral administration or tablets of 125 mg

For infections of the upper and lower respiratory tract, skin and soft tissues (with the exception of chronic erythema migrans), adults are prescribed the drug in dose of 500 mg 1 time / day for 3 days, the course dose - 1.5 g.
Children are prescribed at the rate of 10 mg / kg body weight 1 time / day for 3 days, the course dose is 30 mg / kg.

In chronic erythema migrans:
adults are prescribed the drug 1 time / day for 5 days: 1 day - 1 g (2 tab. 500 mg each), then from 2 to 5 days - 500 mg, the course dose is 3 g.
Children are prescribed at 1 day at a dose of 20 mg / kg body weight and then from 2 to 5 days - daily at a dose of 10 mg / kg body weight, the course dose is 60 mg / kg.

Overdose

Symptoms: nausea, temporary hearing loss, vomiting, diarrhea.

Treatment: symptomatic therapy.

Side effects

The frequency of side effects is classified according to WHO recommendations: very often (≥10%), often (≥1% -<10%), infrequently (≥0.1% -<1%), rarely (≥0.01% - <0.1%), very rarely (<0.01%), unknown frequency (impossible to estimate based on available data).

Infectious diseases: infrequently - candidiasis (including oral mucosa and genitals), pneumonia, pharyngitis, gastroenteritis, respiratory diseases, rhinitis; unknown frequency - pseudomembranous colitis.

From the blood and lymphatic system: infrequently - leukopenia, neutropenia, eosinophilia; very rarely - thrombocytopenia, hemolytic anemia.

From the side of metabolism: infrequently - anorexia.

Allergic reactions: infrequently - angioedema, hypersensitivity reaction; unknown frequency - anaphylactic reaction.

From the nervous system: often - headache; infrequently - dizziness, impaired taste, paresthesia, drowsiness, insomnia, nervousness; rarely - agitation; unknown frequency - hypoesthesia, anxiety, aggression, fainting, convulsions, psychomotor hyperactivity, loss of smell, perversion of the sense of smell, loss of taste, myasthenia gravis, delusions, hallucinations.

From the side of the organ of vision: infrequently - visual impairment.

From the side of the organ of hearing and labyrinth disorders: infrequently - hearing disorder, vertigo; unknown frequency - hearing impairment up to deafness and / or tinnitus.

From the cardiovascular system: infrequently - a feeling of palpitations, flushes of blood to the face; unknown frequency - a decrease in blood pressure, an increase in the QT interval on the ECG, arrhythmia of the "pirouette" type, ventricular tachycardia.

From the respiratory system: infrequently - shortness of breath, nosebleeds.

From the gastrointestinal tract: very often - diarrhea; often - nausea, vomiting, abdominal pain; infrequently - flatulence, dyspepsia, constipation, gastritis, dysphagia, bloating, dryness of the oral mucosa, belching, ulcers of the oral mucosa, increased secretion of salivary glands; very rarely - a change in the color of the tongue, pancreatitis.

From the liver and biliary tract: infrequently - hepatitis; rarely - impaired liver function, cholestatic jaundice; unknown frequency - liver failure (in rare cases with a fatal outcome mainly against the background of severe impairment of liver function), liver necrosis, fulminant hepatitis.

From the skin and subcutaneous tissues: infrequently - skin rash, itching, urticaria, dermatitis, dry skin, sweating; rarely - photosensitization reaction; unknown frequency - Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme.

From the musculoskeletal system: infrequently - osteoarthritis, myalgia, back pain, neck pain; unknown frequency - arthralgia.

From the kidneys and urinary tract: infrequently - dysuria, pain in the kidney area; unknown frequency - interstitial nephritis, acute renal failure.

From the genitals and mammary gland: infrequently - metrorrhagia, impaired testicular function.

Other: infrequently - asthenia, malaise, feeling tired, swelling of the face, chest pain, fever, peripheral edema.

Laboratory data: often - a decrease in the number of lymphocytes, an increase in the number of eosinophils, an increase in the number of basophils, an increase in the number of monocytes, an increase in the number of neutrophils, a decrease in the concentration of bicarbonates in the blood plasma; infrequently - an increase in the activity of AST, ALT, an increase in the concentration of bilirubin in the blood plasma, an increase in the concentration of urea in the blood plasma, an increase in the concentration of creatinine in the blood plasma, a change in the potassium content in the blood plasma, an increase in the activity of alkaline phosphatase in the blood plasma, an increase in the chlorine content in the blood plasma, an increase in the concentration of glucose in the blood, an increase in the concentration of platelets, an increase in the concentration of bicarbonates in the blood plasma, changes in the sodium content in the blood plasma.

Storage conditions
The drug should be stored out of the reach of children at a temperature not exceeding 25°C.
Shelf life 3 years.
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Product Details

Data sheet

Brand
Teva
service_future
otc_08
Dosage form
Capsules
Dosage
250 mg
INN
Azithromycin
Number of tablets
6
INN Russian
Азитромицин
Russian title
Сумамед
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