Tetracycline 100 mg tablets 20 OZON

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100 mg.

Active substance: tetracycline 100 mg.

Excipients: microcrystalline cellulose (MCC-101) - 24.06 mg, potato starch - 3.9 mg, gelatin - 1.04 mg, calcium stearate - 1 mg.

Pharmacological properties

Bacteriostatic antibiotic from the group of tetracyclines. Disrupts the formation of a complex between transport RNA and the ribosome, which leads to suppression of protein synthesis.

It is active against gram-positive microorganisms - Staphylococcus spp. (including Staphylococcus aureus, including penicillinase-producing strains), Streptococcus spp. (some strains, including Streptococcus pneumoniae), Listeria monocytogenes, Bacillus anthracis, Clostridium spp., Actinomyces spp., Propionibacterium acnes, Bacillus fusiformis;

Gram-negative microorganisms are Haemophilus influenzae, Haemophilus ducreyi, Bordetella pertussis, Escherichia coli, Enterobacter spp. (including Enterobacter aerogenes), Klebsiella spp., Neisseria gonorrhoeae, Shigella spp., Yersinia pestis, Bartonella bacilliformis, Vibrio cholerae, Vibrio fetus, Rickettsia prowazekii, Rickettsia rickettsii, Rickettsia akari, Borrelia Vinceni, Borrelia recurrentis, Borrelia burgdorferi, Brucella spp. (in combination with streptomycin); Calymmatobacterium granulomatis, Francisella tularensis, Treponema pallidum, Treponema pertenue;

With contraindications to the appointment of penicillins - Clostridium spp., Neisseria gonorrhoeae, Actinomyces spp.;

Active against Chlamydia trachomatis; Chlamydia psittaci, Entamoeba histolytica;

Microorganisms are resistant to tetracycline: Pseudomonas aeruginosa, Proteus spp.; Serratia spp., most strains of Bacteroides spp. and fungi, viruses, beta-hemolytic streptococci group A (including 44% of strains of Streptococcus pyogenes and 74% of strains of Streptococcus faecalis).

Indications for use

Infectious and inflammatory diseases caused by microorganisms sensitive to tetracycline:

  • pneumonia and respiratory tract infections caused by Mycoplasma pneumoniae respiratory tract infections caused by Haemophilus influenzae and Klebsiella spp.
  • bacterial infections of the genitourinary organs infections of the skin and soft tissues
  • ulcerative-necrotic gingivostomatitis conjunctivitis acne
  • actinomycosis
  • intestinal amebiasis
  • anthrax
  • brucellosis
  • bartonellosis chancroid- cholera chlamydia
  • uncomplicated gonorrhea
  • inguinal granuloma
  • venereal lymphogranuloma
  • listeriosis
  • plague
  • psittacosis
  • vesicular rickötsiosis
  • spotted fever
  • typhus
  • relapsing typhus
  • syphilis
  • trachoma
  • tularemia
  • yaws
  • botulism
  • tetanus
  • gas gangrene
  • food poisoning
  • whooping cough
  • dysentery
  • vibriosis
  • Lyme disease.
  • Hypersensitivity to tetracycline,
  • leukopenia
  • renal failure (CC<50-10 ml / min),
  • pregnancy
  • the period of breastfeeding,
  • children's age up to 8 years.

With caution

Renal failure (CC>80-50 ml / min).

Use in pregnancy and lactation

Contraindicated use during pregnancy and during breastfeeding.

Use in case of impaired liver function
Use with caution in case of impaired liver function.
Use in renal dysfunction

The drug is contraindicated for use in case of impaired renal function

Use in children
Contraindicated in children under 8 years of age. The use of tetracycline in children during the development of teeth can lead to an irreversible change in their color.
Use in elderly patients

In elderly patients, apply taking into account the state of kidney function.

Special instructions

With prolonged use, it is necessary to periodically monitor the functions of the kidneys, liver, hematopoietic organs.

Can mask manifestations syphilis, in connection with which, with the possibility of mixed infection, it is necessary to conduct a monthly serological analysis for 4 months.

All tetracyclines form persistent complexes with calcium ions in any bone-forming tissue. In this regard, the reception during the period of tooth development can cause long-term staining of the teeth in a yellow-gray-brown color, as well as enamel hypoplasia.

During the treatment period, vitamins of group B, K, brewer's yeast should be used to prevent hypovitaminosis.

Tetracycline can not be taken simultaneously with milk and other dairy products, because at the same time the absorption of the antibiotic is disturbed.

In connection with the possible development of photosensitivity, it is necessary to limit insolation.

Drug Interactions

Preparations containing metal ions (antacids, preparations containing iron, magnesium, calcium) form inactive chelates with tetracycline, and therefore it is necessary avoid their simultaneous appointment.

It is necessary to avoid combination with penicillins, cephalosporins, which have a bactericidal effect and are antagonists of bacteriostatic antibiotics (including tetracycline).

With the simultaneous use of tetracycline with retinol, the development of intracranial hypertension is possible.

With simultaneous use with colestyramine or colestipol, there is a violation of the absorption of tetracycline.

Chymotrypsin increases the concentration and duration of tetracycline circulation in the body.

In connection with the suppression of intestinal microflora, it reduces the prothrombin index (requires a reduction in the dose of indirect anticoagulants).

Reduces the effectiveness of estrogen-containing oral contraceptives and increases the risk of "breakthrough" bleeding.

Dosage and Administration

Inside, washed down with plenty of liquid.

Adults - 0.3 - 0.5 g every 6 hours (4 times a day) or 0.5-1 g every 12 hours (2 times a day). The maximum daily dose is 4 g. The course of treatment is 5 - 10 days.

Children over 8 years of age - 6.25 - 12.5 mg / kg every 6 hours or 12.5 - 25 mg / kg every 12 hours.

For acne: 0.5 - 2 g / day in divided doses. In case of improvement (usually after 3 weeks), the dose is gradually reduced to maintenance - 0.1 - 1 g. Adequate remission of acne can be achieved when using the drug every other day or intermittent therapy.

Brucellosis - 0.5 g every 6 hours for 3 weeks, simultaneously with intramuscular administration of streptomycin at a dose of 1 g every 12 hours for 1 week and 1 time per day for 2 weeks.

Uncomplicated gonorrhea - the initial single dose is 1.5 g, then 0.5 g every 6 hours for 4 days (total dose of 9 g).

Syphilis - 0.5 g every 6 hours for 15 days (early syphilis) or 30 days (late syphilis).

Uncomplicated urethral, endocervical and rectal infections caused by Chlamydia trachomatis - 0.5 g every 6 hours for at least 7 days.

Lyme disease (early stage only) - 1.0 - 1.5 g per day for 10 - 14 days.

Listeriosis - 0.2 - 0.3 g every 6 hours for 7 - 10 days.

Actinomycosis - 3 g per day for the first 10 days, then 0.5 g every 6 hours for the last 18 days.

Chlamydia - 1.5 - 2 g per day for 10 days ("fresh" forms) and 15 - 20 days (chronic, complicated forms).

Inguinal granuloma, venereal lymphogranuloma - 0.5 g every 6 hours for 3 - 4 weeks.

Psittacosis - 0.5 g every 6 hours (weakening and disappearance of symptoms of the disease occurs after 24 - 48 hours). Treatment is continued for 7 to 14 days after normalization of body temperature to prevent recurrence.

Vesicular rickettsiosis - 0.8 - 1.2 g per day for 8 - 10 days.

Tularemia - 1.5 - 2 g per day. After normalizing the temperature, treatment continues for another 5 to 7 days.

Yaws - 0.5 g every 6 hours for 14 days.

Plague - up to 6 g per day. With an improvement in the condition, the dose is reduced to 2 g per day until the temperature normalizes, but for at least 3 days. Contact persons should conduct a course of 0.3 g every 6 hours.

Side effects

From the digestive system: decreased appetite, vomiting, diarrhea, nausea, glossitis, esophagitis, gastritis, gastric and duodenal ulceration, hypertrophy of the papillae of the tongue, dysphagia, hepatotoxic effect, increased activity of hepatic transaminases, pancreatitis, stomatitis, colitis, intestinal dysbiosis.

From the nervous system: increased intracranial pressure, headache, dizziness or instability.

With sides of the hematopoietic organs: hemolytic anemia, thrombocytopenia, neutropenia.

From the urinary system: azotemia, hypercreatininemia.

Allergic reactions: maculopapular rash, skin flushing, angioedema, anaphylactoid reactions, drug systemic lupus erythematosus (SLE), photosensitivity, eosinophilia, exfoliative dermatitis, fever, urticaria, arthralgia, pericarditis

Immunological reactions: angioedema, anaphylactoid reactions, drug systemic lupus erythematosus, eosinophilia, fever, urticaria, arthralgia, pericarditis.

From the skin: maculopapular rash, skin hyperemia, photosensitivity, exfoliative dermatitis.

Other: superinfection, candidiasis, hypovitaminosis B, hyperbilirubinemia, discoloration of tooth enamel in children.

Storage conditions
In a dry place at a temperature not exceeding 25 ° C.
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Product Details

Data sheet

Dosage form
100 mg
Number of tablets
INN Russian
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