Amoxicillin 500mg capsules 16

$20.30
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Euro 32/34 36 38 40
USA 0/2 4 6 8
Bust(in) 31-32 33 34 36
Bust(cm) 80.5-82.5 84.5 87 92
Waist(in) 24-25 26 27 29
Waist(cm) 62.5-64.5 66.5 69 74
Hips(in) 34-35 36 37 39
Hips(cm) 87.5-89.5 91.5 94 99
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Description
Country

Serbia

INN

Amoxicillin

Dosage

500 mg

Composition

Amoxicillin trihydrate - 673.9 mg, which corresponds to the content of amoxicillin - 500 mg.

Excipients: magnesium stearate - 9.2 mg, microcrystalline cellulose PH 102 - 26.9 mg.

Composition of the capsule shell: gelatin - up to 96 mg; capsule cap - titanium dioxide (E171) - 0.4992 mg, sunset yellow dye (E110) - 0.13774 mg, azorubin dye (E122) - 0.13336 mg; capsule body - titanium dioxide (E171) - 0.576 mg, iron oxide yellow dye (E172) - 0.26899 mg.

Pharmacological properties

Antibiotic of the group of semi-synthetic penicillins of a wide spectrum of action. It is a 4-hydroxyl analogue of ampicillin. It has a bactericidal effect.

Active against aerobic gram-positive bacteria: Staphylococcus spp. (except for strains, producing penicillinase), Streptococcus spp.; aerobic gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Klebsiella spp.

Microorganisms that produce penicillinase are resistant to amoxicillin.

In combination with metronidazole, it is active against Helicobacter pylori. Amoxicillin is believed to inhibit the development of Helicobacter pylori's resistance to metronidazole.

There is cross-resistance between amoxicillin and ampicillin.

The spectrum of antibacterial action is expanded with the simultaneous use of amoxicillin and the beta-lactamase inhibitor of clavulanic acid.

In this combination, the activity of amoxicillin against Bacteroides spp., Legionella spp., Nocardia spp., Pseudomonas (Burkholderia) pseudomallei is increased.

However, Pseudomonas aeruginosa, Serratia marcescens, and a host of other Gram-negative bacteria. remain resistant.

Pharmacokinetics

When taken orally, amoxicillin is quickly and completely absorbed from the gastrointestinal tract, is not destroyed in the acidic environment of the stomach. C max amoxicillin in the blood plasma is reached after 1-2 hours.

With an increase in the dose by 2 times, the concentration also increases by 2 times. In the presence of food in the stomach does not reduce overall absorption.

With / in, / m administration and ingestion in the blood, similar concentrations of amoxicillin are achieved.

The binding of amoxicillin to plasma proteins is about 20%.

It is widely distributed in tissues and body fluids. High concentrations of amoxicillin in the liver have been reported.

T 1/2 from plasma is 1-1.5 h. About 60% of the dose taken orally is excreted unchanged in the urine by glomerular filtration and tubular secretion; at a dose of 250 mg, the concentration of amoxicillin in the urine is more than 300 μg / ml. Some the amount of amoxicillin is determined in the feces.

In newborns and the elderly T 1/2 may be longer.

In renal failure T 1/2 can be 7-20 hours.

In small quantities, amoxicillin penetrates through the BBB with inflammation of the soft meninges.

Amoxicillin is removed by hemodialysis.

Indications for use

For use in the form of monotherapy and in combination with clavulanic acid: infectious and inflammatory diseases caused by sensitive microorganisms, including bronchitis, pneumonia, sore throat, pyelonephritis, urethritis, gastrointestinal infections, gynecological infections, infectious diseases of the skin and soft tissues, listeriosis, leptospirosis, gonorrhea.

For use in combination with metronidazole: chronic gastritis in the acute phase, peptic ulcer of the stomach and duodenum in the acute phase, associated with Helicobacter pylori.

Contraindications

Infectious mononucleosis, lymphocytic leukemia, severe gastrointestinal infections accompanied by diarrhea or vomiting, respiratory viral infections, allergic diathesis, bronchial asthma, hay fever, hypersensitivity to penicillins and / or cephalosporins.

For use in combination with metronidazole: diseases of the nervous system; hematopoietic disorders, lymphocytic leukemia, infectious mononucleosis; hypersensitivity to nitroimidazole derivatives.

For use in combination with clavulanic acid: indications in the anamnesis of impaired liver function and jaundice associated with the intake of amoxicillin in combination with clavulanic acid.

Dosage and Administration

Individual.

For oral administration, a single dose for adults and children over 10 years of age (with a body weight of more than 40 kg) is 250-500 mg, in severe cases of the disease - up to 1 g.

For children aged 5-10 years, a single dose is 250 mg; at the age of 2 to 5 years - 125 mg. Interval between doses - 8 hours.

For children weighing less than 40 kg, the daily dose, depending on the indications and clinical situation, may be 20-100 mg / kg in 2-3 doses.

In the treatment of acute uncomplicated gonorrhea - 3 g once (in combination with probenecide).

In patients with impaired renal function with CK 10-40 ml / min, the interval between doses should be increased to 12 hours; with A CK of less than 10 ml / min, the interval between doses should be 24 hours.

With parenteral use in adults / m - 1 g 2 times / day, in / in (with normal kidney function) - 2-12 g / day. Children in / m - 50 mg / kg / day, single dose - 500 mg, frequency of administration - 2 times / day; in / in - 100-200 mg / kg / day.

Patients with impaired renal function, the dose and interval between injections should be adjusted in accordance with the values of QC.

Side effects

Allergic reactions: urticaria, erythema, angioedema, rhinitis, conjunctivitis; rarely - fever, joint pain, eosinophilia; in isolated cases - anaphylactic shock.

Effects associated with chemotherapeutic action: the development of superinfections is possible (especially in patients with chronic diseases or reduced body resistance).

With prolonged use in high doses: dizziness, ataxia, confusion, depression, peripheral neuropathies, convulsions.

Mainly when used in combination with metronidazole: nausea, vomiting, anorexia, diarrhea, constipation, epigastrium pain, glossitis, stomatitis; rarely - hepatitis, pseudomembranous colitis, allergic reactions (urticaria, angioedema), interstitial nephritis, hematopoiesis disorders.

Mainly when used in combination with clavulanic acid: cholestatic jaundice, hepatitis; rarely - erythema multiforme, toxic epidermal necrolysis, exfoliative dermatitis.

Storage conditions

In a dry, dark place at a temperature not exceeding 25 ° C. Out of the reach of children.

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Product Details

Data sheet

Brand
Hemofarm
service_future
otc_02
Dosage form
Capsules
Dosage
500 mg
INN
Amoxicillin
Number of tablets
16
INN Russian
Амоксициллин
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