Clarithromycin 250mg tablets 10

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Euro 32/34 36 38 40
USA 0/2 4 6 8
Bust(in) 31-32 33 34 36
Bust(cm) 80.5-82.5 84.5 87 92
Waist(in) 24-25 26 27 29
Waist(cm) 62.5-64.5 66.5 69 74
Hips(in) 34-35 36 37 39
Hips(cm) 87.5-89.5 91.5 94 99
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Active substance: clarithromycin - 250 mg

Excipients: lactose monohydrate - 27.4 mg, povidone (polyvinylpyrrolidone low molecular weight) - 14.5 mg, corn starch - 10.5 mg, croscarmellose sodium - 6.4 mg, talc - 6.4 mg, calcium stearate - 3.2 mg, polysorbate 80 - 1.6 mg.

The composition of hard gelatin capsules: titanium dioxide - 2%, gelatin - up to 100%.

Pharmacological properties

Macrolide bacteriostatic antibiotic of the second generation from the group of macrolides of a wide spectrum of action. Disrupts the protein synthesis of microorganisms (binding the 50S subunity of the ribosome membrane of the microbial cell).

Active against: Streptococcus agalactiae (Staphylococcus pyogenes, Staphylococcus viridans, Staphylococcus pneumoniae), Haemophilus influenzae (parainfluenzae), Haemophilus ducreyi, Neisseria gonorrhoeae, Neisseria meningitidis, Listeria monocytogenes, Legionella pneumophila, Mycoplasma pneumoniae, Helicobacter (Campylobacter) pylori, Campylobacter jejuni, Chlamydia pneumoniae (trachomatis), Moraxella (Branhamella) catarrhalis, Bordetella pertussis, Propionibacterium acnes, Mycobacterium avium, Mycobacterium leprae, Staphylococcus aureus, Ureaplasma urealyticum, Toxoplasma gondii, Corynebacterium spp., Borrelia burgdorferi, Pasteurella multocida, some anaerobes, some anaerobes (Eubacterium spp., Peptococcus spp., Propionibacterium spp., Clostridium perfringens, Bacteroides melaninogenicus) and mycobacteria other than M. tuberculosis.

Indications for use
  • infections of the lower respiratory tract (bronchitis, pneumonia);
  • infections of the upper respiratory tract (pharyngitis, sinusitis, otitis);
  • infections of the skin and soft tissues (folliculitis, erysipelas);
  • common or localized mycobacterial infections caused by Mycobacterium avium and Mycobacterium intracellulare;
  • localized infections caused by Mycobacterium chelonae, Mycobacterium fortuitum and Mycobacterium kansasii;
  • elimination of H. pylori and reduction of the recurrence rate of duodenal ulcers.
  • simultaneous reception of ergot derivatives;
  • during treatment with clarithromycin, it is forbidden to take cisapride, pimozide, astemizole and terfenadine; In patients taking these drugs simultaneously with clarithromycin, there is an increase in their concentration in the blood. In this case, it is possible to prolong the QT interval and the development of cardiac arrhythmias, including ventricular paroxysmal tachycardia, ventricular fibrillation and fluttering or flickering of the ventricles;
  • severe impairment of liver and / or kidney function;
  • hypersensitivity to antibiotics from the group of macrolides.
Use in pregnancy and lactation

The safety of clarithromycin during pregnancy and lactation has not been established. Therefore, during pregnancy, clarithromycin is prescribed only in the absence of alternative therapy, if the intended benefit exceeds the possible risk to the fetus.

Clarithromycin penetrates into breast milk, therefore, if necessary, the appointment of the drug during lactation should stop breastfeeding.

Use in case of impaired liver function

Contraindicated in severe violations of liver function.

Use in renal dysfunction

In patients with renal insufficiency, with creatinine clearance of less than 30 ml / min, the dose of the drug should be reduced by 2 times. The maximum duration of the course in patients in this group should be no more than 14 days.

Use in children

For children, the drug is prescribed at a dose of 7.5 mg / kg body weight / day. The maximum daily dose is 500 mg. The duration of the course of treatment is 7-10 days.

Special instructions

In the presence of chronic liver disease, it is necessary to conduct regular monitoring of serum enzymes.

With caution, they are prescribed against the background of drugs metabolized by the liver (it is recommended to measure their concentration in the blood).

In the case of joint appointment with warfarin or other indirect anticoagulants, it is necessary to control the prothrombin time.

In case of heart disease in the anamnesis, simultaneous administration with terfenadine, cisapride, astemizole is not recommended.

It is necessary to pay attention to the possibility of cross-resistance between clarithromycin and other antibiotics from the group of macrolides, as well as lincomycin and clindamycin.

With prolonged or repeated use of the drug, the development of superinfection (growth of insensitive bacteria and fungi) is possible.


Symptoms: nausea, vomiting, diarrhea, headache, confusion.

Treatment: in case of overdose, immediate gastric lavage and symptomatic treatment are necessary. Hemodialysis and peritoneal dialysis do not lead to a significant change in the level of clarithromycin in the blood serum.

Dosage and Administration

For adults, the average dose for oral administration is 250 mg 2 times / day. If necessary, you can prescribe 500 mg 2 times / day. The duration of the course of treatment is 6-14 days.

For children, the drug is prescribed at a dose of 7.5 mg / kg body weight / day. The maximum daily dose is 500 mg. Duration of treatment is 7-10 days.

For the treatment of infections caused by Mycobacterium avium, clarithromycin is prescribed orally - 1 g 2 times / day. The duration of treatment can be 6 months or more.

In patients with renal insufficiency, with creatinine clearance of less than 30 ml / min, the dose of the drug should be reduced by 2 times. The maximum duration of the course in patients of this the group must be no more than 14 days.

Side effects

The most common complaints from the digestive system are nausea, dyspepsia, abdominal pain, vomiting and diarrhea. There are reports of the development of pseudomembranous colitis from moderate to life-threatening. Other adverse reactions include headaches, taste disturbances and a transient increase in the activity of liver enzymes.

There are reports of rare cases of parasthesia.

There are reports of rare cases of hepatitis with an increase in the level of liver enzymes in the blood and the development of cholestasis and jaundice. This liver damage in some cases was severe and usually reversible. In exceptional cases, liver failure with a fatal outcome was observed.

There are reports of rare cases of an increase in serum creatinine concentration, the development of interstitial nephritis, the development of renal failure.

When taking clarithromycin orally, allergic reactions were observed, the intensity of which ranged from urticaria and skin rash, to anaphylaxis and Stevens-Johnson syndrome.

There are reports of hearing loss during treatment with clarithromycin, which in most cases recovered after discontinuation of the drug. Changes in taste perception are also reported, usually occurring along with a taste disturbance.

There are reports of the development of glossitis, stomatitis, candidiasis of the oral mucosa and a change in the color of the tongue during treatment with clarithromycin. A change in the color of the teeth in patients receiving clarithromycin is also reported. The change in tooth color in most cases was reversible.

In rare cases, hypoglycemia was noted; in some of these cases, hypoglycemia developed in patients who took hypoglycemic agents for oral administration or insulin during treatment with clarithromycin.

Isolated cases of thrombocytopenia have been reported and Radiation.

When taking clarithromycin, transient side effects on the central nervous system were observed: dizziness, anxiety, fear, fear, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis and depersonalization.

In the treatment with clarithromycin, as with the use of other macrolides, it is extremely rare to observe an extension of the QT interval, ventricular arrhythmia, incl. ventricular paroxysmal tachycardia and fluttering or flickering of the ventricles.

Storage conditions

In a dry, protected from light, out of the reach of children, at a temperature not exceeding 25 ° C.

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Product Details

Data sheet

Dosage form
250 mg
Number of tablets
INN Russian
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