Leflobakt 500mg tablets 10

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Women's clothing size
Euro 32/34 36 38 40
USA 0/2 4 6 8
Bust(in) 31-32 33 34 36
Bust(cm) 80.5-82.5 84.5 87 92
Waist(in) 24-25 26 27 29
Waist(cm) 62.5-64.5 66.5 69 74
Hips(in) 34-35 36 37 39
Hips(cm) 87.5-89.5 91.5 94 99
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With your arms relaxed at your sides, measure around the fullest part of your chest.

How To Measure Your Waist

Measure around the narrowest part of your natural waist, generally around the belly button. To ensure a comfortable fit, keep one finger between the measuring tape and your body.

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Active substances: levofloxacin (in the form of hemihydrate) -500 mg

Excipients: calcium stearate, starch 1500, potato starch, crospovidone (collidone CL-M), povidone, lactose, talc, microcrystalline cellulose.

Shell composition: hypromellose, macrogol, titanium dioxide, tropoline 0.

Pharmacological properties

Leflobakt ® - synthetic antimicrobial bactericidal preparation of a wide spectrum of action from the group of fluoroquinolones.

Levofloxacin is a levorocative isomer of ofloxacin. Levofloxacin blocks the enzymes DNA gyrase (topoisomerase II) and topoisomerase IV, disrupts the supercoilation and cross-linking of DNA breaks, causes deep morphological changes in the cytoplasm, cell wall and membrane of bacteria.

Levofloxacin is active against most strains of microorganisms both in vitro and in vivo.

Gram-positive aerobic microorganisms: Staphylococcus spp. (coagulazonegative, methicillin-sensitive/moderately methicillin-sensitive strains), Staphylococcus aureus (methicillin-sensitive strains), Staphylococcus epidermidis (methicillin-sensitive strains), Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus pneumoniae (penicillin-sensitive/moderately penicillin-sensitive/penicillin-resistant strains), Streptococcus spp (groups C, G), Streptococcus viridans (penicillin-sensitive and penicillin-resistant strains), Enterococcus faecalis, Corynebacterium diphtheriae, Listeria monocytogenes.

Gram-negative aerobic microorganisms: Acinetobacter spp. (including Acinetobacter anitratus, Acinetobacter baumannii, Acinetobacter calcoaceticus), Actinobacillus actinomycetemcomitans, Citrobacter freundii, Citrobacter diversus, Eikenella corrodens, Enterobacter spp. (incl. Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter cloacae, Enterobacter sakazakii), Escherichia coli, Gardnerella vaginalis, Haemophilus ducreyi, Haemophilus influenzae (ampicillin-sensitive/ampicillin-resistant strains), Haemophilus parainfluenzae, Helicobacter pylori, Klebsiella spp. (including Klebsiella oxytoca, Klebsiella pneumoniae), Moraxella catarrhalis, Morganella morganii, Neisseria gonorrhoeae (including penicillinase-producing strains), Neisseria meningitidis, Pasteurella spp. (including Pasteurella canis, Pasteurella dagmatis, Pasteurella multocida), Proteus mirabilis, Proteus vulgaris, Providencia spp. (including Providencia rettgeri, Providencia stuartii), Pseudomonas spp. (including Pseudomonas aeruginosa, Pseudomonas fluorescens), Salmonella spp., Serratia spp. (including Serratia marcescens).

Anaerobic microorganisms: Bacteroides fragilis, Bifidobacterium spp., Clostridium perfringens, Fusobacterium spp., Peptostreptococcus spp., Propionibacterium spp., Veillonella spp.

Other microorganisms: Bartonella spp., Chlamydia (Chlamydophila) pneumoniae, Chlamydia psittaci, Chlamydia trachomatis, Legionella spp. (including Legionella pneumophila), Mycobacterium spp. (including Mycobacterium leprae, Mycobacterium tuberculosis), Mycoplasma hominis, Mycoplasma pneumoniae, Rickettsia spp., Ureaplasma urealyticum.

Indications for use

Infectious and inflammatory diseases caused by microorganisms sensitive to levofloxacin:

  • lower respiratory tract (chronic bronchitis, pneumonia);
  • ENT organs (sinusitis, otitis media);
  • genitourinary organs (acute pyelonephritis, prostatitis, urogenital chlamydia);
  • skin and soft tissues (suppurated atheromas, abscess, boils).

As part of the complex therapy of drug-resistant forms of tuberculosis.

  • epilepsy;
  • tendon damage with previous treatment with quinolones;
  • impaired renal function in CK<20 ml / min;
  • hemodialysis;
  • pregnancy;
  • lactation period;
  • children and adolescents up to 18 years;
  • hypersensitivity to the components of the drug.

With caution, the drug should be used with a deficiency of glucose-6-phosphate dehydrogenase, in elderly patients (high probability of the presence of concomitant decline in renal function).

Use in pregnancy and lactation

Contraindicated use of the drug during pregnancy and during breastfeeding.

Use in renal dysfunction

Contraindicated use of the drug in case of impaired renal function in CK<20 ml / min, when on hemodialysis.

Use in children

The drug is contraindicated for use in children and adolescents under 18 years of age.

Use in elderly patients

With caution, the drug should be used in elderly patients (high probability of a concomitant decrease in renal function).

Special instructions

After normalizing body temperature, it is recommended to continue treatment for at least 48-72 hours.

During treatment, it is necessary to avoid solar and artificial UV irradiation in order to avoid damage to the skin (photosensitivity).

If signs of tendinitis, pseudomembranous colitis appear, levofloxacin should be immediately canceled.

In patients with a history of brain damage (including stroke, severe trauma), seizures may develop; with glucose-6-phosphate dehydrogenase deficiency, the risk of hemolysis increases.

Influence on the ability to drive vehicles and control mechanisms

During the period of treatment, caution should be exercised when driving motor transport and engaging in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.


Symptoms: nausea, erosive lesions of the mucous membranes of the gastrointestinal tract, prolongation of the QT interval, confusion, dizziness, convulsions.

Treatment: symptomatic, gastric lavage, dialysis is ineffective. There is no specific antidote.

Dosage and Administration

The drug should be taken orally before meals or in between meals, without chewing, with a sufficient amount of liquid (from 0.5 to 1 cup).

With exacerbation of chronic bronchitis, 250-500 mg is prescribed 1 time / day for 7-10 days.

With community-acquired pneumonia, 500 mg is prescribed 1-2 times / day for 7-14 days.

With sinusitis, 500 mg is prescribed 1 time / day for 10-14 days.

Uncomplicated urinary tract infections prescribe 250 mg 1 time / day for 3 days.

For complicated urinary tract infections (including pyelonephritis) - 250 mg 1 time / day for 7-10 days.

With prostatitis, 500 mg is prescribed 1 time / day for 28 days.

For infections of the skin and soft tissues, 250-500 mg 1-2 times / day for 7-14 days is prescribed.

As part of the complex therapy of drug-resistant forms of tuberculosis, 500 mg 1-2 times / day (500-1000 mg / day) up to 3 months are indicated.

Levofloxacin is excreted mainly by the kidneys, therefore, in the treatment of patients with limited renal function, it is required to reduce the dose of the drug.

It is possible to prescribe Leflobact in the form of tablets to continue the course of treatment to those patients who were first prescribed intravenous administration of Leflobact in the form of an infusion solution and an improvement in their condition was achieved, allowing further administration of levofloxacin inside.

Side effects

From the digestive system: nausea, vomiting, diarrhea (including with blood), digestive disorders, decreased appetite, abdominal pain, pseudomembranous enterocolitis, increased activity of hepatic transaminosis, hyperbilirubinemia, hepatitis, dysbacteriosis.

From the cardiovascular system: a decrease in blood pressure, vascular collapse, tachycardia, prolongation of the QT interval.

From the side of metabolism: hypoglycemia (including increased appetite, increased sweating, trembling).

From the nervous system: headache, dizziness, weakness, drowsiness, insomnia, tremor, anxiety, paresthesia, fear, hallucinations, confusion, depression, movement disorders, epileptic seizures (in predisposed patients).

From the senses: visual impairment, hearing, smell, taste and tactile sensitivity.

From the musculoskeletal system: arthralgia, muscle weakness, myalgia, tendon rupture, tendonitis, rhabdomyolysis.

From the urinary system: ipercreatininemia, interstitial nephritis, acute renal failure.

From the hematopoietic system: eosinophilia, hemolytic anemia, leukopenia, neutropenia, agranulocytosis, thrombocytopenia, pancytopenia, hemorrhage.

Allergic reactions: itching and hyperemia of the skin, swelling of the skin and mucous membranes, urticaria, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), bronchospasm, suffocation, anaphylactic shock, allergic pneumonitis, vasculitis.

Other: asthenia, exacerbation of porphyria, photosensitivity, persistent fever, development of superinfection.

Storage conditions

List B. The drug should be stored out of the reach of children, a dry, dark place at a temperature not exceeding 25 ° C.

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Product Details

Data sheet

Dosage form
500 mg
Number of tablets
INN Russian
Russian title
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