Loperamide-Akrikhin 2mg capsules 20
Women's clothing size
| Size | XS | S | M | L |
|---|---|---|---|---|
| Euro | 32/34 | 36 | 38 | 40 |
| USA | 0/2 | 4 | 6 | 8 |
| Bust(in) | 31-32 | 33 | 34 | 36 |
| Bust(cm) | 80.5-82.5 | 84.5 | 87 | 92 |
| Waist(in) | 24-25 | 26 | 27 | 29 |
| Waist(cm) | 62.5-64.5 | 66.5 | 69 | 74 |
| Hips(in) | 34-35 | 36 | 37 | 39 |
| Hips(cm) | 87.5-89.5 | 91.5 | 94 | 99 |
With your arms relaxed at your sides, measure around the fullest part of your chest.
Measure around the narrowest part of your natural waist, generally around the belly button. To ensure a comfortable fit, keep one finger between the measuring tape and your body.
Country
Russia
INN
Loperamide
Dosage
2mg
Composition
Active substance: loperamide hydrochloride 2 mg.
Excipients: lactose monohydrate (milk sugar) - 127 mg, corn starch - 40 mg, talc - 9 mg, magnesium stearate - 2 mg.
Composition of the capsule body: red iron oxide dye - 0.0071%, iron oxide yellow dye - 0.1227%, titanium dioxide - 2%, gelatin - up to 100%.
Composition of the capsule lid: quinoline yellow dye - 0.75%, sunset yellow dye - 0.0059%, titanium dioxide - 2%, gelatin - up to 100%.
Pharmacological properties
Loperamide, binding to opioid receptors of the intestinal wall (stimulation of choline and adrenergic neurons through guanine nucleotides), reduces the tone and motility of the smooth muscles of the intestine (by inhibiting the release of acetylcholine and prostaglandins). Slows down peristalsis and increases the transit time of intestinal contents. Increases the tone of the sphincter, helps to retain feces and reduce the urge to defecate. The action develops quickly and lasts 4-6 hours.
Pharmacokinetics
When ingested, absorption is 40%. C max in plasma is achieved 2.5 hours after taking capsules. The connection with plasma proteins (mainly with albumins) is 97%. Does not penetrate the BBB. It is almost completely metabolized by the liver by conjugation. T 1/2 - 9-14 hours in (an average of 9.8 hours). It is excreted mainly with bile, a small part is excreted by the kidneys (in the form of conjugated metabolites).
Indications for use
- symptomatic treatment of acute and chronic diarrhea of various genesis (allergic, emotional, medicinal, radiation);
- with a change in the diet and qualitative composition of food, with a violation of metabolism and suction;
- as an adjuvant in diarrhea of infectious genesis;
- regulation of stool in patients with ileostomy.
Contraindications
- Hypersensitivity to the drug, lactose intolerance, lactase deficiency or glucose-galactose malabsorption;
- diverticulosis, intestinal obstruction, ulcerative colitis in the acute stage;
- diarrhea on the background of acute pseudomembranous enterocolitis, in the form of monotherapy - dysentery and other infections of the gastrointestinal tract;
- pregnancy (I trimester), lactation;
- loperamide capsules are not prescribed to children under 6 years of age.
With caution: liver failure.
Use in pregnancy and lactation
Contraindicated in the first trimester of pregnancy. In the II and III trimesters of pregnancy, loperamide can be prescribed in cases where the expected benefit therapy for the mother exceeds the potential risk to the fetus.
Since a small amount of loperamide is found in breast milk, it is not recommended to take it during breastfeeding.
Special instructions
In the absence of effect after 2 days of using Loperamide, you should consult a doctor.
If constipation or bloating develop during treatment, loperamide should be discontinued. In patients with impaired liver function, careful monitoring of signs of toxic damage to the central nervous system is necessary.
During the treatment of diarrhea, it is necessary to replenish the loss of fluid and electrolytes.
During the period of treatment, care must be taken when driving vehicles and engaging in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.
Use in case of impaired liver function
Patients with disabilities are used with caution liver function, with liver failure.
Use in children
Contraindicated in children under 4 years of age.
Dosage and Administration
Adults with acute diarrhea, the first dose is 4 mg, then 2 mg after each act of defecation in the case of loose stools. In chronic diarrhea, the first dose is 2 mg, the maintenance dose is selected so that the frequency of the stool is 1-2 times per day (2-12 mg / day).
The maximum daily dose for adults is 16 mg.
Children aged 4-8 years - 1 mg 3-4 times / day for 3 days; 9-12 years - 2 mg 4 times / day for 5 days.
Overdose
Symptoms: depression of the central nervous system (stupor, impaired coordination, drowsiness, miosis, muscle hypertension, respiratory depression), intestinal obstruction.
Treatment: antidote - naloxone; given that the duration of action of loperamide is longer than that of naloxone, it is possible to re-administer Last.
Symptomatic treatment: activated charcoal, gastric lavage, artificial ventilation of the lungs.
Medical supervision is necessary for at least 48 hours.
Side effects
From the digestive system: abdominal pain, bloating, nausea, constipation, dry mouth.
From the side of the central nervous system: increased fatigue, drowsiness, dizziness.
Allergic reactions: skin rash.
Storage conditions
Store in a dry, dark place at a temperature not exceeding 25 ° C.
Shelf life: 2 years.
Keep out of reach of children.
Data sheet
- Brand
- Akrikhin
- service_future
- otc_01
- Dosage form
- Capsules
- Dosage
- 2 mg
- INN
- Loperamide
- Number of tablets
- 20
- INN Russian
- Лоперамид
- Russian title
- Лоперамид-Акрихин