Nemozole 400mg tablets 1
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Active substance: albendazole 400 mg;
Excipients: corn starch, sodium lauryl sulfate, povidone-30, methylparaben, propylparaben, citric acid, gelatin, talc purified, sodium starch glycolate, silicon dioxide colloidal, magnesium stearate, aspartame, pineapple flavor, mint flavor.
Anthelmintic drug. The main mechanism of action is associated with an inhibitory effect on the polymerization of beta-tubulin, which leads to the destruction of cytoplasmic microchannels of cells of the intestinal tract of helminths; changes the course of biochemical processes (inhibits the utilization of glucose), blocks the movement of secretory granules and other organelles in the muscle cells of roundworms, causing their death. The most active against the larval forms of cestodes - Echinococcus granulosus and Taenia solium, nematodes - Strongyloides stercolatis.
Indications for use
- nematodoses (ascariasis, enterobiasis, hookworm, necatorosis, trichocephalosis);
- mixed helminthic invasions;
- neurocysticercosis caused by the larval form of Taenia solium;
- echinococcosis of the liver, lungs, peritoneum, caused by the larval form of Echinococcus granulosus;
- as an adjuvant in the surgical treatment of echinococcosis cysts.
- retinal damage;
- hypersensitivity to the components of the drug and other derivatives of benzimidazole.
Use with caution in case of violation of hematopoiesis, impaired liver function (before and during treatment should be regularly monitored liver function), during breastfeeding.
Use in pregnancy and lactation
The drug is contraindicated for use during pregnancy. If it is necessary to prescribe the drug during lactation, the issue of stopping breastfeeding should be resolved.
Before prescribing the drug, a test should be conducted for the absence of pregnancy in women of childbearing age. During the period of therapy, reliable methods of contraception should be used.
Use in case of impaired liver function
With caution it is used for violations of liver function (before and during treatment, liver function should be regularly monitored).
Use in children
It is possible to use according to indications and in doses that take into account the age of patients.
With neurocysticercosis, appropriate therapy with corticomon and anticonvulsants should be carried out. GCS for oral or intravenous administration is used to prevent hypertensive attack in the first week of anti-nazi therapy.
Monitoring of laboratory parameters
Against the background of the use of the drug, it is recommended to control the cellular composition of the blood. If leukopenia occurs, therapy is suspended.
Blood tests should be performed at the beginning of each 28-day cycle every 2 weeks during the period of albendazole therapy. It is possible to continue treatment with albendazole if the decrease in the total content of leukocytes and neutrophilic leukocytes is moderate and does not progress.
Dosage and Administration
The average therapeutic dose in the treatment of nematodes for adults and children over 2 years of age is 400 mg or 20 ml of suspension inside once.
The drug is taken during meals. It is recommended to carry out simultaneous treatment of all family members.
With neurocysticercosis and echinococcosis, patients weighing 60 kg or more are prescribed the drug at 400 mg 2 times / day; with body weight less than 60 kg dose is set at the rate of 15 mg / kg / day in 2 doses. The maximum daily dose is 800 mg (400 mg 2 times / day). The course of treatment for neurocysticercosis is 8-30 days; with echinococcosis - 3 cycles of 28 days with a 14-day interval between cycles.
With giardiasis, children are prescribed the drug at the rate of 10-15 mg / kg 1 time / day for 5-7 days.
With toxocariasis, adults and children over 14 years of age with a body weight of more than 60 kg are prescribed 400 mg 2 times / day; with a body weight of less than 60 kg - 200 mg 2 times / day; children under 14 years of age are given a dose of 10 mg / kg 2 times / day. The duration of therapy is 7-14 days.
Treatment: gastric lavage, activated charcoal. If necessary, symptomatic therapy is performed.
From the digestive system: impaired liver function with a change in functional liver tests (mild or moderate increase in transaminosis activity), pain in the region abdomen, nausea, vomiting.
From the hematopoietic system: leukopenia, granulocytopenia, agranulocytosis, thrombocytopenia, pancytopenia.
From the side of the central nervous system: headache, dizziness, meningeal symptoms.
Dermatological reactions: reversible alopecia, skin rash, itching.
Other: fever, increased blood pressure, acute renal failure, allergic reactions.
In a dry, dark place, at a temperature below 25 ° C.
Shelf life: 3 years.
Keep out of reach of children.
- Ipca Laboratories Ltd
- Dosage form
- 400 mg
- Number of tablets
- INN Russian