ACC 600mg powder 3g pack 6 (Acetylcysteine)

$20.30
Size chart
Women's clothing size
SizeXSSML
Euro 32/34 36 38 40
USA 0/2 4 6 8
Bust(in) 31-32 33 34 36
Bust(cm) 80.5-82.5 84.5 87 92
Waist(in) 24-25 26 27 29
Waist(cm) 62.5-64.5 66.5 69 74
Hips(in) 34-35 36 37 39
Hips(cm) 87.5-89.5 91.5 94 99
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With your arms relaxed at your sides, measure around the fullest part of your chest.

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Measure around the narrowest part of your natural waist, generally around the belly button. To ensure a comfortable fit, keep one finger between the measuring tape and your body.

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2 33% $13.40
3 38% $23.14
4 46% $37.35
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Description
Country

Germany

INN

Acetylcysteine

Dosage

600 mg

Composition

Acetylcysteine - 600 mg;

excipients: sucrose - 2045 mg, ascorbic acid - 75 mg, sodium saccharinate - 20 mg, lemon flavor - 130 mg, honey flavor - 130 mg.

Pharmacological properties

Mucolytic drug. Acetylcysteine is a derivative of the amino acid cysteine. It has a mucolytic effect, facilitates the discharge of sputum due to a direct effect on the rheological properties of sputum.

The action is due to the ability to break the disulfide bonds of the mucopolysaccharide chains and cause depolymerization of sputum flour proteins, which leads to a decrease in the viscosity of sputum.

The drug remains active in the presence of purulent sputum.

It has an antioxidant effect due to the ability of its reactive sulfhydryl groups (SH- To bind to oxidative radicals and thus neutralize them.

In addition, acetylcysteine promotes the synthesis of glutathione, an important component of the antioxidant system and chemical detoxification of the body.

The antioxidant effect of acetylcysteine increases the protection of cells from the damaging effect of free radical oxidation, characteristic of an intense inflammatory reaction.

With the prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations in patients with chronic bronchitis and cystic fibrosis.

Pharmacokinetics

Suction and distribution

Absorption is high. Bioavailability when ingested is 10%, which is due to the pronounced effect of the "first passage" through the liver. Reach time C max in the blood plasma is 1-3 hours.

Binding to blood plasma proteins - 50%. It penetrates the placental barrier. There is no data on the ability of acetylcysteine to penetrate the BBB and be excreted in breast milk.

Metabolism and excretion

It is rapidly metabolized in the liver with the formation of a pharmacologically active metabolite - cysteine, as well as diacetylcysteine, cystine and mixed disulfides.

It is excreted by the kidneys in the form of inactive metabolites (inorganic sulfates, diacetylcysteine). T 1/2 is about 1 hour.

Pharmacokinetics in special clinical cases

Impaired liver function leads to prolongation of T 1/2 up to 8 h.

Indications for use
  • respiratory diseases accompanied by the formation of viscous hard-to-separate sputum (acute and chronic bronchitis, obstructive bronchitis, tracheitis, laryngotracheitis, pneumonia, lung abscess, bronchiectasis, bronchial asthma, COPD, bronchiolitis, cystic fibrosis);
  • acute and chronic sinusitis;
  • otitis media.
Contraindications
  • peptic ulcer of the stomach and duodenum in the acute phase;
  • hemoptysis;
  • pulmonary hemorrhage;
  • pregnancy;
  • lactation (breastfeeding);
  • children's age up to 2 years (syrup, granules for oral solution /orange/ 100 mg and 200 mg);
  • children's age up to 6 years (granules for the preparation of a solution for oral administration 200 mg);
  • children's age up to 14 years (granules for the preparation of a solution for oral administration 600 mg);
  • fructose intolerance, because the drug contains sorbitol (granules for the preparation of a solution for oral administration / orange / 100 mg and 200 mg, granules for the preparation of a solution for oral administration 200 mg and 600 mg);
  • deficiency of sucrase/ isomaltase, glucose-galactose deficiency (granules for oral solution /orange/ 100 mg and 200 mg, granules for oral solution 200 mg and 600 mg);
  • hypersensitivity to acetylcysteine and other components of the drug.

With caution the drug should be used in patients with peptic ulcer of the stomach and duodenum in the anamnesis; with bronchial asthma, obstructive bronchitis; hepatic and / or renal failure; histamine intolerance (long-term use of the drug should be avoided, because acetylcysteine affects the metabolism of histamine and can lead to signs of intolerance, such as headache, vasomotor rhinitis, itching); varicose veins of the esophagus; diseases of the adrenal glands; Hypertension.

Dosage and Administration

Adults and adolescents over 14 years of age are recommended to prescribe the drug by 200 mg 2-3 times / day. The daily dose is 400-600 mg.

Children aged 6 to 14 years are recommended to take 100 mg 3 times / day or 200 mg 2 times / day. The daily dose is 300-400 mg.

Children aged 2 to 5 years, the drug is recommended to take 100 mg 2-3 times / day. The daily dose is 200-300 mg.

With cystic fibrosis for children over the age of 6 years, the drug is recommended to take 200 mg 3 times / day. The daily dose is 600 mg.

Children aged 2 to 5 years - 100 mg 4 times / day. The daily dose is 400 mg.

Patients weighing more than 30 kg with cystic fibrosis, if necessary, can increase the dose to 800 mg / day.

With short-term colds, the duration of admission is 5-7 days. In chronic bronchitis and cystic fibrosis, the drug should be used for a longer time to prevent infections. In long-term diseases, the duration of therapy is determined by the attending physician.

Preparation taken orally after meals. Additional fluid intake enhances the mucolytic effect of the drug.

ATT ® in the form of granules for the preparation of a solution for oral administration (orange) 100 mg and 200 mg are dissolved in water, juice or cold tea.

ATT ® in the form of granules for the preparation of a solution for oral administration, 200 mg is dissolved when stirred in 1 cup of hot water and drunk, if possible, hot. If necessary, you can leave the prepared solution for 3 hours.

Side effects

According to WHO, undesirable effects are classified according to their incidence as follows: very often (≥1/10), often (≥1/100, <1/10), infrequently (≥1/1000, <1/100), rarely (≥1/10,000, <1/1000) and very rarely (<10,000), the frequency is unknown (the incidence cannot be determined from the available data).

Allergic reactions: infrequently - skin itching, rash, exanthema, urticaria, angioedema; very rarely - anaphylactic reactions up to shock, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome).

From the respiratory system: rarely - shortness of breath, bronchospasm (mainly in patients with bronchial hyperreactivity in bronchial asthma).

From the cardiovascular system: infrequently - a decrease in blood pressure, tachycardia.

From the digestive system: infrequently - stomatitis, abdominal pain, nausea, vomiting, diarrhea, heartburn, dyspepsia.

From the side of the organ of hearing: infrequently - tinnitus.

Other: rarely - headache, fever; in isolated cases - the development of bleeding as a manifestation of a reaction of hypersensitivity, a decrease in platelet aggregation.

Storage conditions

The drug should be stored out of the reach of children at a temperature not exceeding 25 ° C.

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Product Details

Data sheet

Brand
Lindopharm GmbH
service_future
otc_02
Dosage form
Powder
Dosage
600mg
INN
Acetylcysteine
Number of tablets
6 packets of 3 g each
INN Russian
Ацетилцистеин
Russian title
АЦЦ
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