Bromhexine 8 Berlin-Chemi 8mg dragee 25
Women's clothing size
| Size | XS | S | M | L |
|---|---|---|---|---|
| Euro | 32/34 | 36 | 38 | 40 |
| USA | 0/2 | 4 | 6 | 8 |
| Bust(in) | 31-32 | 33 | 34 | 36 |
| Bust(cm) | 80.5-82.5 | 84.5 | 87 | 92 |
| Waist(in) | 24-25 | 26 | 27 | 29 |
| Waist(cm) | 62.5-64.5 | 66.5 | 69 | 74 |
| Hips(in) | 34-35 | 36 | 37 | 39 |
| Hips(cm) | 87.5-89.5 | 91.5 | 94 | 99 |
With your arms relaxed at your sides, measure around the fullest part of your chest.
Measure around the narrowest part of your natural waist, generally around the belly button. To ensure a comfortable fit, keep one finger between the measuring tape and your body.
Country
Germany
INN
Bromhexine
Dosage
8 mg
Composition
1 dragee contains 8 mg of bromhexine hydrochloride.
Excipients: lactose monohydrate - 34.4 mg, corn starch - 14.6 mg, gelatin - 1.8 mg, silicon dioxide colloidal - 0.6 mg, magnesium stearate - 0.6 mg.
Shell composition: sucrose - 27.704 mg, calcium carbonate - 4.326 mg, magnesium carbonate - 1.507 mg, talc - 1.507 mg, macrogol 6000 - 1.75 mg, povidone K25 - 0.243 mg, glucose syrup - 1.639 mg, carnauba wax - 0.012 mg, titanium dioxide (E171) - 1.166 mg, quinoline yellow (E104) - 0.146 mg.
Pharmacological properties
Flourlytic agent with expectorant effect.
Reduces the viscosity of bronchial secretion due to the depolarization of the acidic polysaccharides contained in it and stimulation of the secretory cells of the bronchial mucosa, which produce a secret containing neutral polysaccharides.
It is believed that bromhexine contributes to the formation of surfactant.
Pharmacokinetics
Bromhexine is rapidly absorbed from the digestive tract and undergoes intensive metabolism during the "first passage" through the liver. Bioavailability is about 20%. In healthy patients C max in plasma is determined after 1 hour.
It is widely distributed in the tissues of the body. About 85-90% is excreted in the urine mainly in the form of metabolites. The metabolite of bromhexine is ambroxol.
The binding of bromhexine to plasma proteins is high. T 1/2 in the terminal phase is about 12 hours.
Bromhexine penetrates through the BBB. In small quantities, it penetrates the placental barrier.
Only small amounts are excreted in the urine with T 1/2 6.5 h.
Clearance of bromhexine or its metabolites may decrease in patients with severe impairment of liver and kidney function.
Indications for use
Respiratory diseases accompanied by the formation of a hard-to-separate viscous secretion:
- tracheobronchitis,
- chronic bronchitis with a bronchoobstructive component,
- bronchial asthma,
- Cystic fibrosis
- chronic pneumonia.
Contraindications
Hypersensitivity to bromhexine.
Dosage and Administration
Inside adults and children over 10 years old - 8 mg 3-4 times / day. Children under the age of 2 years - 2 mg 3 times / day; at the age of 2 to 6 years - 4 mg 3 times / day; at the age of 6 to 10 years - 6-8 mg 3 times / day. If necessary, the dose can be increased for adults up to 16 mg 4 times / day, for children - up to 16 mg 2 times / day.
In the form of inhalations for adults - 8 mg, children over 10 years old - 4 mg, at the age of 6-10 years - 2 mg. At the age of 6 years - used in doses up to 2 Mg. Inhalations are carried out 2 times / day.
The therapeutic effect may occur on the 4-6th day of treatment.
Parenteral administration is recommended for treatment in severe cases, as well as in the postoperative period to prevent the accumulation of thick sputum in the bronchi. Inject 2 mg p / k, / m or in / in 2-3 times / day slowly for 2-3 minutes.
Side effects
From the digestive system: dyspeptic phenomena, transient increase in the activity of hepatic transaminazes in the blood serum.
From the side of the central nervous system: headache, dizziness.
Dermatological reactions: increased sweating, skin rash.
From the respiratory system: cough, bronchospasm.
Storage conditions
At a temperature not exceeding 25 ° C.
Data sheet
- Brand
- Berlin-Chemie
- service_future
- otc_04
- Dosage form
- Dragee
- Dosage
- 8 mg
- INN
- Bromhexine
- Number of tablets
- 25
- INN Russian
- Бромгексин