Libexin 100mg tablets 20
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Active substance: prenoxdiazine hydrochloride 100 mg.
Excipients: glycerol (glycerin), magnesium stearate, talc, povidone, corn starch, lactose monohydrate.
Prenoxdiazine is an antitussive agent of peripheral action. The drug blocks the peripheral links of the cough reflex due to the following effects: local anesthetic effect, which reduces the irritability of the peripheral sensitive (cough) receptors of the respiratory tract; bronchodilator action, due to which there is a suppression of stretch receptors involved in the cough reflex; a slight decrease in the activity of the respiratory center (without respiratory depression). The antitussion effect of the drug is approximately equal to that of codeine.
Prenoxdiazine is not is addictive and drug dependence. In chronic bronchitis, the anti-inflammatory effect of prenoxdiazine has been noted.
Prenoxdiazine does not affect the function of the central nervous system, except for a possible indirect anxiolytic effect.
Indications for use
- unproductive cough of any origin (with catarrh of the upper respiratory tract, influenza, acute and chronic bronchitis, pneumonia, emphysema);
- night cough in patients with heart failure;
- when preparing patients for bronchoscopic or bronchographic examination).
- diseases associated with abundant bronchial secretion;
- condition after inhalation anesthesia;
- galactose intolerance, lactase deficiency or glucose-galactose malabsorption;
- hypersensitivity to the drug.
With caution: children's age
Use in pregnancy and lactation
During pregnancy and lactation, the use of Libexin is possible only if the potential benefit to the mother exceeds the possible risk to the fetus or child.
Use in children
With caution: children's age.
The drug can cause complaints from the gastrointestinal tract in patients with lactose intolerance, because tablets contain lactose (0.38 mg of lactose in each tablet).
Impact on the ability to drive vehicles and perform work associated with increased danger
Taking the drug in high doses can slow down the rate of reactions, therefore, when taking the drug in high doses, the question of the possibility of driving a car or doing work associated with increased danger should be decided individually.
Not it is recommended to combine the drug with muculytic and expectorants, because it can complicate the release of sputum, diluted by the latter. There are no preclinical or clinical data on interactions with other drugs.
Dosage and Administration
The average dose for adults is 100 mg 3-4 times / day (1 tab. 3-4 times / day). In more complex cases, the dose can be increased to 200 mg 3-4 times / day or up to 300 mg 3 times / day (2 tab. 3-4 times / day or 3 tablets 3 times / day).
The average dose for children, depending on age and body weight, is 25-50 mg three or four times a day (1/4 - 1/2 tab. 3-4 times / day).
The maximum single dose for children is 50 mg (1/2 tab.), for adults - 300 mg (3 tab.). The maximum daily dose for children is 200 mg (2 tab.), for adults - 900 mg (9 tab.).
In preparation for bronchoscopy, a dose of 0.9-3.8 mg / kg of body weight is combined with 0.5-1 mg of atropine 1 hour before the start Procedures.
Tablets are swallowed without chewing (in order to avoid anesthesia of the oral mucosa).
Data on overdose for humans are not available. In the case of taking a dose exceeding the therapeutic, the development of a sedative effect and weakness is possible.
Allergic reactions: rarely - skin rash; angioedema.
From the gastrointestinal tract: rarely - dry mouth or throat; anesthesia (temporary numbness and loss of sensitivity) of the oral mucosa; in less than 10% of cases - pain in the stomach; tendency to constipation; nausea.
From the nervous system: when using the drug in high doses - a slight sedative effect; Fatigue.
It should be emphasized that both sedation and fatigue occur at doses above therapeutic, and all symptoms spontaneously cease within a few hours after discontinuation. taking the drug.
Store at a temperature not exceeding 25 ° C. Keep out of the reach of children.
Shelf life - 5 years.
- Dosage form
- 100 mg
- Number of tablets
- INN Russian
- Russian title