Advantan 0,1% cream for external use 15 g

$37.10
Size chart
Women's clothing size
SizeXSSML
Euro 32/34 36 38 40
USA 0/2 4 6 8
Bust(in) 31-32 33 34 36
Bust(cm) 80.5-82.5 84.5 87 92
Waist(in) 24-25 26 27 29
Waist(cm) 62.5-64.5 66.5 69 74
Hips(in) 34-35 36 37 39
Hips(cm) 87.5-89.5 91.5 94 99
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With your arms relaxed at your sides, measure around the fullest part of your chest.

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Volume discounts

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2 19% $14.10
3 22% $24.49
4 26% $38.58
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Description
Country

Italy

INN

Methylprednisolone Aceponat

Dosage

0,1%

Composition

methylprednisolone aceponate - 1 mg;

excipients: decyloleate - 100 mg, glyceryl monostearate 40-55% - 85 mg, cetostearyl alcohol (cetyl alcohol 60%, stearyl alcohol 40%) - 25 mg, solid fat - 25 mg, softizan 378 - 75 mg, macrogol stearate - 30 mg, glycerol 85% - 50 mg, disodium edetate - 1 mg, benzyl alcohol - 10 mg, butyl hydroxytoluene - 60 μg, purified water - 597.94 mg.

Pharmacological properties

When applied externally, Advantan ® suppresses inflammatory and allergic skin reactions, as well as reactions associated with increased proliferation, which leads to a decrease in objective symptoms of inflammation (including erythema, edema, weeing, etc.) and subjective sensations (including itching, irritation, pain, etc.).

When used methylprednisolone aceponate externally in the recommended dose, the systemic effect is minimally expressed in both humans and animals.

After repeated application of Advantan on large surfaces (40-60% of the skin surface), as well as when used under an occlusive dressing, there is no violation of the adrenal functions: the level of cortisol in the blood plasma and its circadian rhythm remain within normal limits, there is no decrease in the level of cortisol in the daily urine.

In the course of clinical studies with the use of Advantan up to 12 weeks in adults and up to 4 weeks in children (including early age), the development of skin atrophy, telangiectasias, striae and acne-like rashes was not detected.

Methylprednisolone aceponate (especially its main metabolite, 6α-methylprednisolone-17-propionate) binds to intracellular glucocorticoid receptors.

The steroid receptor complex binds to specific stretches of the DNA of immune response cells, thus causing a series of biological effects.

In particular, the binding of the steroid-receptor complex to the DNA of immune response cells leads to the induction of macrocortin synthesis.

Macrocortin inhibits the release of arachidonic acid and thereby the formation of inflammatory mediators such as prostaglandins and leukotrienes.

Inhibition of GCS synthesis of vasodilating prostaglandins and potentiation of the vasoconstrictor effect of adrenaline leads to a vasoconstrictor effect.

Pharmacokinetics

Suction

The degree of percutaneous absorption depends on the condition of the skin, the dosage form and the method of application (with or without the use of an occlusive dressing).

When using an ointment, cream or fatty ointment, percutaneous absorption in children and adults with atopic dermatitis (neurodermatitis) and psoriasis was no more than 2.5%, which is only slightly higher compared to healthy volunteers (0.5-1.5%).

When used the drug in the form of an emulsion was very low (0.27%), which is only slightly higher than through healthy skin (0.17%).

In the case of whole-body treatment (for example, with sunburn), the systemic dose is about 4 μg / kg body weight / day, which excludes systemic effects.

Metabolism and excretion

Methylprednisolone aceponat is hydrolyzed in the epidermis and dermis. The main and most active metabolite is 6α-methylprednisolone-17-propionate, which has a significantly higher affinity for glucocorticoid receptors of the skin, which indicates the presence of its bioactivation in the skin.

After entering the systemic circulation, 6α-methylprednisolone-17-propionate is rapidly conjugated with glucuronic acid and, thus, in the form of 6α-methylprednisolone-17-propionate glucuronide is inactivated.

Metabolites of methylprednisolone aceponate are eliminated mainly by the kidneys, T 1/2 - about 4 p.m.

Methylprednisolone aceponate and its metabolites do not cumulate in the body.

Indications for use

Inflammatory skin diseases sensitive to therapy with topical corticoticoticonics:

  • atopic dermatitis, neurodermatitis, childhood eczema;
  • true eczema;
  • microbial eczema;
  • professional eczema;
  • dyshidrotic eczema;
  • simple contact dermatitis;
  • allergic (contact) dermatitis.
Contraindications
  • tuberculous or syphilitic processes in the area of application of the drug;
  • viral diseases in the area of application of the drug (for example, with chickenpox, shingles);
  • rosacea, perioral dermatitis in the area of application of the drug;
  • areas of skin with reactions to vaccination;
  • children's age up to 4 months;
  • hypersensitivity to the components of the drug.
Dosage and Administration

Outwardly.

Adults and children from 4 months of age apply the drug 1 time / day in a thin layer on the affected skin.

Continuous daily use of Advantan in the form of a cream should not exceed 12 weeks for adults, 4 weeks for children.

The cream is a dosage form with a low fat content and a high water content, so it is recommended for subacute and acute inflammation without pronounced weeping. The cream ensures the elimination of the inflammatory process both on smooth skin and on the scalp, incl. on skin prone to oiliness.

Side effects

Usually the drug is well tolerated.

Very rarely (less than 0.01% of cases) local reactions such as itching, burning, erythema, formation can be observed vesicular rash.

If the drug is used for more than 4 weeks and / or on an area of 10% or more of the body surface, the following reactions may occur: skin atrophy, telangiectasias, striae, acneform skin changes, systemic effects due to the absorption of the corticosteroid.

In clinical trials, none of the above side effects were noted with the use of advantan ® up to 12 weeks in adults and up to 4 weeks in children.

In rare cases (0.01-0.1%), folliculitis, hypertrichosis, perioral dermatitis, skin depigmentation, allergic reactions to one of the components of the drug can be observed.

Storage conditions

Store at a temperature not exceeding 25°C.

The drug should be stored out of the reach of children.

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Product Details

Data sheet

Brand
Bayer
service_future
otc_14
Dosage form
Cream
Dosage
15 g
INN
Methylprednisolone Aceponat
INN Russian
Метилпреднизолона ацепонат
Russian title
Адвантан
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