Comfoderm 0,1% ointment for external use 15g
Women's clothing size
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|methylprednisolone aceponate (in terms of 100% substance)||100 mg|
Excipients: petroleum jelly - 44.7 g, liquid paraffin - 34.1 g, castor oil - 3.2 g, white beeswax - 17.9 g.
GCS for external use. Suppresses the functions of leukocytes and tissue macrophages. Restricts the migration of leukocytes to the area of inflammation. Disrupts the ability of macrophages to phagocytosis, as well as to the formation of interleukin-1. Helps stabilize lysosomal membranes, thereby reducing the concentration of proteolytic enzymes in the area of inflammation. Reduces capillary permeability due to the release of histamine. Inhibits the activity of fibroblasts and the formation of collagen.
Inhibits the activity of phospholipase A2, which leads to suppression of the synthesis of prostaglandins and leukotrienes. Inhibits the release of COX (mainly COX-2), which also helps to reduce the production of prostaglandins.
Reduces the number of circulating lymphocytes (T- and B-cells), monocytes, eosinophils and basophils due to their movement from the vascular bed to the lymphoid tissue; inhibits the formation of antibodies.
Methylprednisolone aceponat suppresses the release of ACTH and ?-lipotropin by the pituitary gland, but does not reduce the level of circulating ?-endorphins. Inhibits the secretion of TSH and FSH.
With direct application to the vessels causes a vasoconstrictor effect.
With external and topical use, the therapeutic activity of methylprednisolone is due to anti-inflammatory, antiallergic and anti-exudative (due to the vasoconstrictor effect) effect.
Indications for use
- Inflammatory skin diseases sensitive to therapy with topical glucocorticosteroids:
- atopic dermatitis, neurodermatitis, childhood eczema;
- true eczema;
- microbial eczema
- professional eczema;
- simple contact dermatitis;
- allergic (contact) dermatitis;
- dyshidrotic eczema.
- tuberculous or syphilitic processes in the area of application of the drug;
- viral diseases (for example, chicken pox, shingles), in the area of application of the drug;
- rosacea, perioral dermatitis in the area of application of the drug;
- children's age up to 4 months;
- skin areas with manifestations of a reaction to vaccination;
- hypersensitivity to the components of the drug.
Dosage and Administration
Apply externally 1 time / day with a thin layer on the affected area, slightly rubbing. It can be used with an occlusive dressing. Usually, the course of treatment is for adults no more than 12 weeks, and for children - no more than 4 weeks. During the year, it is possible to conduct several courses of therapy.
The incidence of side effects is classified according to WHO recommendations: very often (≥10%), often (≥1%, <10%), infrequently (≥0.1%, <1%), rarely (≥0.01%, <0.1%), very rarely (<0.01%), frequency is unknown (it is not possible to estimate the frequency of occurrence).
From the skin and subcutaneous tissues: rarely - perioral dermatitis, skin depigmentation, allergic reactions to the components of the drug; frequency unknown - skin atrophy, telangiectasia, striae, acne-like skin changes (when using the drug for more than 4 weeks and / or on an area of 10% or more of the body surface).
General disorders and disorders at the injection site: rarely - folliculitis, hypertrichosis; very rarely - itching, burning, erythema, the formation of vesicular rash; frequency unknown - systemic effects due to absorption of GCS (when using the drug for more than 4 weeks and / or on an area of 10% or more of the body surface).
If any of the side effects indicated in the instructions are aggravated or any other side effects not indicated in the instructions are noted, the patient should immediately inform the doctor.
The drug should be stored out of the reach of children at a temperature not exceeding 25 ° C.
- Dosage form
- Methylprednisolone Aceponat
- INN Russian
- Метилпреднизолона ацепонат
- Russian title