Nifedipine 10 mg tablets 50

Country

Active ingredient

Composition

Active ingredients: nifedipine - 10 mg;
Auxiliary substances: magnesium stearate, microcrystalline cellulose, lactose monohydrate, potato starch, colloidal silicon dioxide (aerosil), povidone (polyvinylpyrrolidone low molecular weight medical).

Pharmacological action

Nifedipine is a selective blocker of "slow calcium ropes", a derivative of 1,4-dihydropyridine. It has antianginal and antihypertensive action. Reduces the flow of extracellular calcium ions into cardiomyocytes and smooth muscle cells of the coronary and peripheral arteries. Reduces spasm and expands the coronary and peripheral (mainly arterial) vessels, lowers blood pressure, total peripheral vascular resistance, reduces afterload and myocardial oxygen demand. Increases coronary blood flow. Negative chrono-, dromo- and inotropic action is blocked by reflex activation of the sympathoadrenal system in response to peripheral vasodilatation. Enhances renal blood flow, causes moderate natriuresis. The onset of the clinical effect is 20 minutes, the duration of the clinical effect is 4-6 hours.

Indications

Ischemic heart disease - angina pectoris and rest (including variant); arterial hypertension (in the form of monotherapy or in combination with other antihypertensive drugs).

Contraindications

hypersensitivity to nifedipine and other dihydropyridine derivatives; acute stage of myocardial infarction (first 4 weeks);

cardiogenic shock, collapse; arterial hypotension (systolic blood pressure below 90 mm Hg);

sick sinus syndrome; heart failure (in the stage of decompensation);

severe aortic stenosis; severe mitral stenosis; tachycardia; idiopathic hypertrophic subaortic stenosis;

pregnancy, lactation; age up to 18 years (efficacy and safety have not been established). Use with caution in patients: with chronic heart failure, severe violations of the liver and / or kidneys; severe disorders of cerebral circulation, diabetes mellitus, malignant arterial hypertension, patients on hemodialysis (due to the risk of arterial hypotension).