Lorista 25 mg tablets 30

$20.30
Size chart
Women's clothing size
SizeXSSML
Euro 32/34 36 38 40
USA 0/2 4 6 8
Bust(in) 31-32 33 34 36
Bust(cm) 80.5-82.5 84.5 87 92
Waist(in) 24-25 26 27 29
Waist(cm) 62.5-64.5 66.5 69 74
Hips(in) 34-35 36 37 39
Hips(cm) 87.5-89.5 91.5 94 99
How To Measure Your Bust

With your arms relaxed at your sides, measure around the fullest part of your chest.

How To Measure Your Waist

Measure around the narrowest part of your natural waist, generally around the belly button. To ensure a comfortable fit, keep one finger between the measuring tape and your body.

Volume discounts

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2 33% $13.40
3 38% $23.14
4 46% $37.35
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Description
Country
Russia
Active ingredient
Losartan
Dosage
25 mg.
Composition
Active substance: losartan potassium 25 mg.

Excipients: cellactose (a mixture of lactose monohydrate and cellulose), pregelatinized starch, corn starch, microcrystalline cellulose, anhydrous colloidal silicon dioxide, magnesium stearate.

Shell composition: hypromellose, talc, propylene glycol, quinoline yellow dye (E104), titanium dioxide (E171)

Pharmacological properties
Antihypertensive agent. It is a non-peptide blocker of angiotensin II receptors. It has a high selectivity and affinity for AT receptors 1 (with the participation of which the main
effects of angiotensin II). Blocking specified receptors, losartan
prevents and eliminates the vasoconstrictive effect of angiotensin II, its
stimulating effect on the secretion of aldosterone by the adrenal glands and
some other effects of angiotensin II.
action (24 hours or more), which is due to the formation of its active
metabolite.
Indications for use
  • arterial hypertension;
  • reducing the risk of stroke in patients with arterial hypertension and left ventricular hypertrophy;
  • chronic heart failure (as part of combination therapy, with intolerance or ineffectiveness of therapy with ACE inhibitors);
  • protection of renal function in patients with type 2 diabetes mellitus with proteinuria in order to reduce proteinuria, reduce the progression of kidney damage, reduce the risk of developing the terminal stage (prevention of the need for dialysis, the likelihood of an increase in serum creatinine levels) or death.
Contraindications

Pregnancy, lactation, childhood and adolescence up to 18 years, hypersensitivity to losartan.

Use in pregnancy and lactation

Contraindicated for use during pregnancy and lactation.

Use in case of impaired liver function

In patients with a history of liver disease, losartan should be used in low doses. With cirrhosis of the liver, the concentration of losartan in the blood plasma increases significantly.

Use in renal dysfunction

In case of impaired renal function, it may be necessary to reduce the dose of losartan.

Use in children

Safety and efficacy the use of losartan in children has not been established.

Use in elderly patients

In elderly patients during the treatment period, the level of potassium in the blood should be regularly monitored

Special instructions

With caution should be used for arterial hypotension, a decrease in BCC, disturbances in the water-electrolyte balance, bilateral stenosis of the renal arteries or stenosis of the artery of a single kidney, with renal / hepatic insufficiency

Patients who have a deficiency of fluid and / or sodium, before starting treatment, it is necessary to correct water-electrolyte disorders or apply a lower initial dose.

In patients with dehydration (for example, receiving treatment with diuretics in high doses), symptomatic arterial hypotension may occur at the beginning of treatment with losartan.

In case of impaired renal function, a dose reduction may be required losartana.

In patients with a history of liver disease, losartan should be used in low doses. With cirrhosis of the liver, the concentration of losartan in the blood plasma increases significantly.

During the treatment period, the level of potassium in the blood should be regularly monitored, especially in elderly patients, with impaired renal function.

The simultaneous use of losartan with potassium-sparing diuretics should be avoided.

The safety and efficacy of losartan in children have not been established.

Drug Interactions

With simultaneous use with diuretics in high doses, arterial hypotension is possible.

With simultaneous use with potassium preparations, potassium-sparing diuretics, the risk of developing hyperkalemia increases.

With simultaneous use with indomethacin, it is possible to reduce the effectiveness of losartan.

There is a report of the development of lithium intoxication with simultaneous use with lithium carbonate.

With simultaneous use with orlistat, the antihypertensive effect of losartan decreases, which can lead to a significant increase in blood pressure, the development of a hypertensive crisis.

With simultaneous use with rifampicin, the clearance of losartan increases and its effectiveness decreases.

Dosage and Administration
Lorista is taken orally, regardless of food intake.
The frequency of admission is 1 time per day.
Arterial hypertension: the average daily dose is 50 mg. The maximum antihypertensive effect is achieved within 3-6 weeks of therapy. In some patients, a more pronounced effect can be achieved by increasing the dose of the drug to 100 mg / day in 2 or 1 dose.
Against the background of taking large doses of diuretics, it is recommended to start Lorist therapy with 25 mg / day in 1 dose.
In elderly patients, as well as in patients with impaired renal function, including patients on hemodialysis, correction of the initial dose is not required.
It is not necessary to adjust the dose to elderly patients or patients with impaired renal function, including patients on hemodialysis.
Patients with impaired liver function should be prescribed lower doses of the drug.
Chronic heart failure: the initial dose is 12.5 mg / day in 1 dose. In order to achieve the usual maintenance dose of 50 mg / day, the dose of the drug should be increased gradually, at intervals of one week (for example, 12.5; 25 or 50 mg with a single dose per day). Lorista is usually prescribed in combination with diuretics and cardiac glycosides.
The dose of the drug should be increased according to the following scheme:
1st week (1-7th day) - 1 tablet. 12.5 mg/day.
2nd week (8-14th day) - 1 table. 25 mg/day.
3rd week (15-21st day) - 1 table. 50 mg/day.
4th week (22-28th day) - 1 tablet. 50 mg/day.
Overdose

Symptoms: a pronounced decrease in blood pressure, tachycardia; as a result of parasympathetic (vagal) stimulation, bradycardia may develop.

Treatment: forced diuresis, symptomatic therapy. Hemodialysis is ineffective.

Side effects
In most cases, Lorista is well tolerated, side effects are mild and transient and do not require discontinuation of the drug.
From the side of the blood system: infrequently - anemia, Schönlein-Henoch disease.
Allergic reactions: less than 1% - urticaria, skin rash, itching, angioedema (including swelling of the larynx and tongue, causing airway obstruction and / or swelling of the face, lips, pharynx).
From the side of the central nervous system and sensory organs: with a frequency of 1% or more - dizziness, asthenia, headache, fatigue, insomnia; less than 1% - anxiety, sleep disturbance, drowsiness, memory disorders, peripheral neuropathy, paresthesia, hypoesthesia, migraine, tremor, ataxia, depression, syncope, ringing in the ears, impaired taste, visual impairment, conjunctivitis.
From the cardiovascular system: orthostatic hypotension (dose-dependent), palpitations, tachy- or bradycardia, arrhythmias, angina pectoris, vasculitis.
From the genitourinary system: with a frequency of less than 1% - imperative urge to urinate, urinary tract infections, impaired renal function, decreased libido, impotence.
From the respiratory system: with a frequency of 1% or more - nasal congestion, cough *, upper respiratory tract infections, pharyngitis, dyspnea, bronchitis, swelling of the nasal mucosa.
From the digestive tract: with a frequency of 1% or more - nausea, diarrhea *, dyspeptic phenomena *, abdominal pain; less than 1% - anorexia, dry mouth, dental pain, vomiting, flatulence, gastritis, constipation, hepatitis, impaired liver function.
From the skin: with a frequency of less than 1% - dry skin, erythema, photosensitivity, increased sweating, alopecia.
From the musculoskeletal system: with a frequency of 1% or more - convulsions, myalgia *, pain in the back, chest, legs; less than 1% - arthralgia, arthritis, pain in the shoulder, knee, fibromyalgia.
Laboratory parameters: hyperkalemia; infrequently - a moderate increase in the level of urea and creatinine in the blood serum; very rarely - increased activity of liver enzymes, hyperbilirubinemia.
Other: gout.
The "*" sign indicates side effects, the incidence of which is comparable to placebo.
Storage conditions
In a dark place, at a temperature not exceeding 25 ° C.
Shelf life 5 years
Pharmacological properties
Antihypertensive means. It is a non-peptide blocker of angiotensin II receptors. It has a high selectivity and affinity for AT receptors 1 (with the participation of which the main
effects of angiotensin II). Blocking these receptors, losartan
prevents and eliminates the vasoconstrictive effect of angiotensin II, its
stimulating effect on the secretion of aldosterone by the adrenal glands and
some other effects of angiotensin II.
action (24 hours or more), which is due to the formation of its active
metabolite.
Indications for use
  • arterial hypertension;
  • reducing the risk of stroke in patients with arterial hypertension and left ventricular hypertrophy;
  • chronic heart failure (as part of combination therapy, with intolerance or ineffectiveness of inhibitor therapy ACE);
  • protection of renal function in patients with type 2 diabetes mellitus with proteinuria in order to reduce proteinuria, reduce the progression of kidney damage, reduce the risk of developing the terminal stage (preventing the need for dialysis, the likelihood of an increase in serum creatinine levels) or death.
Contraindications

Pregnancy, lactation, childhood and adolescence up to 18 years, hypersensitivity to losartan.

Use in pregnancy and lactation

Contraindicated for use during pregnancy and lactation.

Use in case of impaired liver function

In patients with a history of liver disease, losartan should be used in low doses. With cirrhosis of the liver, the concentration of losartan in the blood plasma increases significantly.

Use in case of function disorders Kidney

In case of impaired renal function, it may be necessary to reduce the dose of losartan.

Use in children

The safety and efficacy of losartan in children have not been established.

Use in elderly patients

In elderly patients during the treatment period, the level of potassium in the blood should be regularly monitored

Special instructions

With caution should be used for arterial hypotension, a decrease in BCC, disturbances in the water-electrolyte balance, bilateral stenosis of the renal arteries or stenosis of the artery of a single kidney, with renal / hepatic insufficiency

Patients who have a deficiency of fluid and / or sodium, before starting treatment, it is necessary to correct water-electrolyte disorders or apply a lower initial dose.

In patients with dehydration (for example, receiving treatment with diuretics in high doses) at the beginning treatment with losartan may cause symptomatic arterial hypotension.

In case of impaired renal function, it may be necessary to reduce the dose of losartan.

In patients with a history of liver disease, losartan should be used in low doses. With cirrhosis of the liver, the concentration of losartan in the blood plasma increases significantly.

During the treatment period, the level of potassium in the blood should be regularly monitored, especially in elderly patients, with impaired renal function.

The simultaneous use of losartan with potassium-sparing diuretics should be avoided.

The safety and efficacy of losartan in children have not been established.

Drug Interactions

With simultaneous use with diuretics in high doses, arterial hypotension is possible.

With simultaneous use with potassium preparations, potassium-sparing diuretics, the risk of developing hyperkalemia.

With simultaneous use with indomethacin, it is possible to reduce the effectiveness of losartan.

There is a report of the development of lithium intoxication with simultaneous use with lithium carbonate.

With simultaneous use with orlistat, the antihypertensive effect of losartan decreases, which can lead to a significant increase in blood pressure, the development of a hypertensive crisis.

With simultaneous use with rifampicin, the clearance of losartan increases and its effectiveness decreases.

Dosage and Administration
Lorista is taken orally, regardless of food intake.
The frequency of admission is 1 time per day.
Arterial hypertension: the average daily dose is 50 mg. The maximum antihypertensive effect is achieved within 3-6 weeks of therapy. In some patients, a more pronounced effect can be achieved by increasing the dose of the drug to 100 mg / day in 2 or 1 dose.
Against the background of taking large doses of diuretics, it is recommended to start Lorist therapy with 25 mg / day in 1 dose.
In elderly patients, as well as in patients with impaired renal function, including patients on hemodialysis, correction of the initial dose is not required.
It is not necessary to adjust the dose to elderly patients or patients with impaired renal function, including patients on hemodialysis.
Patients with impaired liver function should be prescribed lower doses of the drug.
Chronic heart failure: the initial dose is 12.5 mg / day in 1 dose. In order to achieve the usual maintenance dose of 50 mg / day, the dose of the drug should be increased gradually, at intervals of one week (for example, 12.5; 25 or 50 mg with a single dose per day). Lorista is usually prescribed in combination with diuretics and cardiac glycosides.
The dose of the drug should be increased according to the following scheme:
Week 1 (1-7th day) - 1 tablet. 12.5 mg/day.
2nd week (8-14th day) - 1 table. 25 mg/day.
3rd week (15-21st day) - 1 table. 50 mg/day.
4th week (22-28th day) - 1 tablet. 50 mg/day.
Overdose

Symptoms: a pronounced decrease in blood pressure, tachycardia; as a result of parasympathetic (vagal) stimulation, bradycardia may develop.

Treatment: forced diuresis, symptomatic therapy. Hemodialysis is ineffective.

Side effects
In most cases, Lorista is well tolerated, side effects are mild and transient and do not require discontinuation of the drug.
From the side of the blood system: infrequently - anemia, Schönlein-Henoch disease.
Allergic reactions: less than 1% - urticaria, skin rash, itching, angioedema (including swelling of the larynx and tongue, causing airway obstruction and / or swelling of the face, lips, pharynx).
From the side of the central nervous system and sensory organs: with a frequency of 1% or more - dizziness, asthenia, headache, fatigue, insomnia; less than 1% - anxiety, sleep disturbance, drowsiness, memory disorders, peripheral neuropathy, paresthesia, hypoesthesia, migraine, tremor, ataxia, depression, syncope, ringing in the ears, impaired taste, visual impairment, conjunctivitis.
From the cardiovascular system: orthostatic hypotension (dose-dependent), palpitations, tachy- or bradycardia, arrhythmias, angina pectoris, vasculitis.
From the genitourinary system: with a frequency of less than 1% - imperative urge to urinate, urinary tract infections, impaired renal function, decreased libido, impotence.
From the respiratory system: with a frequency of 1% or more - nasal congestion, cough *, upper respiratory tract infections, pharyngitis, dyspnea, bronchitis, swelling of the nasal mucosa.
From the digestive tract: with a frequency of 1% or more - nausea, diarrhea *, dyspeptic phenomena *, abdominal pain; less than 1% - anorexia, dry mouth, toothache, vomiting, flatulence, gastritis, constipation, hepatitis, impaired liver function.
From the skin: with a frequency of less than 1% - dry skin, erythema, photosensitivity, increased sweating, alopecia.
From the musculoskeletal system: with a frequency of 1% or more - convulsions, myalgia *, pain in the back, chest, legs; less than 1% - arthralgia, arthritis, pain in the shoulder, knee, fibromyalgia.
Laboratory parameters: hyperkalemia; infrequently - a moderate increase in the level of urea and creatinine in the blood serum; very rarely - increased activity of liver enzymes, hyperbilirubinemia.
Other: gout.
The "*" sign indicates side effects, the incidence of which is comparable to placebo.
Storage conditions
In a dark place, at a temperature not exceeding 25 ° C.
Shelf life 5 years
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Product Details

Data sheet

Brand
KRKA
service_future
otc_02
Dosage form
Tablets
Dosage
25 mg
INN
Losartan
Number of tablets
30
INN Russian
Лозартан
Russian title
Лориста
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