Rimantadine Actitab 50 mg tablets 20

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Active ingredient: rimantadine hydrochloride 50 mg.

pharmachologic effect

antiviral agent.

Pharma action:

Rimantadine Aktitab - an antiviral agent, a derivative of adamantane; effective against strains of influenza A virus, Herpes simplex type I and II viruses, tick-borne encephalitis viruses (Central European and Russian spring-summer from the group of arboviruses of the Flaviviridae family).

It has antitoxic and immunomodulatory effects. The polymer structure ensures long-term circulation of rimantadine in the body, which allows it to be used not only for therapeutic, but also for prophylactic purposes.

Being a weak base, it increases the pH of endosomes that have a membrane of vacuoles and surround viral particles after they enter the cell. Prevention of acidification in these vacuoles blocks the fusion of the viral envelope with the endosome membrane, thus preventing transfer of viral genetic material into the cytoplasm of the cell. Rimantadine also inhibits the release of viral particles from the cell, i.e., interrupts the transcription of the viral genome.

Prophylactic administration of rimantadine at a daily dose of 200 mg reduces the risk of influenza, and also reduces the severity of influenza symptoms and serological reaction. Some therapeutic effect may also appear when it is administered in the first 18 hours after the development of the first symptoms of influenza.


After oral administration, it is almost completely absorbed in the intestine. Absorption is slow. The time to reach maximum concentration (TCmax) is 1-4 hours. Communication with plasma proteins is about 40%. Distribution volume: adults - 17-25 l / kg, children - 289 liters. The concentration in the nasal secretion is 50% higher than the plasma concentration.

The value of the maximum concentration (Cmax) when taking 100 mg 1 time per day is 181 ng / ml, 100 mg 2 times a day - 416 ng / ml. Metabolized in the liver. The half-life (T1 / 2) in adults 20-44 years old is 25-30 hours, in elderly patients (71-79 years old) and in patients with chronic liver failure - about 32 hours, in children 4-8 years old - 13-38 h; more than 90% is excreted by the kidneys within 72 hours, mainly in the form of metabolites, 15% - unchanged.

In chronic renal failure (CRF), T1 / 2 increases by 2 times. In persons with renal insufficiency and in the elderly, it can accumulate in toxic concentrations if the dose is not adjusted in proportion to the decrease in creatinine clearance (CC). Hemodialysis has little effect on the clearance of rimantadine.


Early treatment and prevention of influenza A in adults and children over 7 years of age.


- Hypersensitivity to rimantadine.

- Acute liver diseases;

- Acute and chronic kidney disease;

- Thyrotoxicosis;

- Pregnancy and lactation;

- Children's age (up to 7 years);


Arterial hypertension, epilepsy (including history), atherosclerosis of cerebral vessels, chronic renal failure, liver failure.

Side effects

From the digestive system: epigastric pain, flatulence, increased blood bilirubin levels, dry mouth, anorexia, nausea, vomiting, gastralgia.

From the side of the central nervous system: headache, insomnia, nervousness, dizziness, impaired concentration, drowsiness, anxiety, irritability, fatigue.

Other: allergic reactions.


With the simultaneous use of rimantadine reduces the effectiveness of antiepileptic drugs.

Adsorbents, astringents and enveloping agents reduce the absorption of rimantadine.

Means that acidify urine (ammonium chloride, ascorbic acid) reduce the effectiveness of rimantadine (due to increased excretion by the kidneys).

Urine alkalizing agents (acetazolamide, sodium bicarbonate) enhance its effectiveness (reducing renal excretion).

Paracetamol and acetylsalicylic acid reduce the Cmax of rimantadine by 11%.

Cimetidine reduces the clearance of rimantadine by 18%.

How to take, course of administration and dosage

Inside (after eating), drinking water, according to the following scheme:

Adults are prescribed on the first day of the disease 100 mg 3 times; on the second and third days you can take 100 mg 2 times; on the fourth day 100 mg once. On the first day of the disease, it is possible to use the drug once at a dose of 300 mg.

Children from 7 to 10 years old are prescribed 50 mg 2 times a day; 11-14 years 50 mg 3 times a day. Treatment of influenza A should begin within 24-48 hours after the onset of symptoms of the disease and continue for 5-7 days. The optimal duration has not been established.

For the prevention of influenza in adults, 50 mg is prescribed once a day for 10-15 days, depending on the source of infection.

For the treatment of influenza in chronic renal failure (CC less than 10 ml / min), severe liver failure, elderly patients in nursing homes - 100 mg 1 time per day.

Special Instructions

Compared to amantadine, it has a higher clinical efficacy and is less toxic.

The emergence of drug-resistant viruses is possible.

In influenza caused by virus B, rimantadine has an antitoxinic action.

When using rimantadine, exacerbation of chronic concomitant diseases is possible. Elderly patients with arterial hypertension have an increased risk of hemorrhagic stroke. With indications of a history of epilepsy and ongoing anticonvulsant therapy against the background of the use of rimantadine, the risk of developing an epileptic seizure increases. In such cases, rimantadine is used at a dose of 0.1 g per day simultaneously with anticonvulsant therapy.

Prophylactic administration is effective in contacts with sick people (taking the drug is necessary for at least 10 days after contact), with the spread of infection in closed groups and with a high risk of illness during an influenza epidemic.

During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.

Active substance


Dosage form



ARVI, Influenza, Tick-borne encephalitis, Influenza prevention

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Product Details

Data sheet

OBL Pharm
Dosage form
50 mg
Number of tablets
INN Russian
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