Arbidol 100mg caps 40
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umifenevir hydrochloride (in the form of umifenovir hydrochloride monohydrate) -100 mg;
Excipients: potato starch - 30.14 mg, microcrystalline cellulose - 55.76 mg, colloidal silicon dioxide (aerosil) - 2 mg, povidone K25 (collidon 25) - 10.1 mg, calcium stearate - 2 mg.
The composition of the capsule body: titanium dioxide (E171) - 2%, gelatin - up to 100%.
The composition of the capsule cap: titanium dioxide (E171) - 1.3333%, sunset dye yellow (E110) - 0.0044%, quinoline yellow (E104) - 0.9197%, gelatin - up to 100%.
Specifically suppresses in vitro influenza viruses A and B (Influenza virus A, B), including highly pathogenic subtypes A(H1N1)pdm09 and A(H5N1), as well as others viruses - causative agents of SARS (coronavirus (Coronavirus), associated with severe acute respiratory syndrome (SARS), rhinovirus (Rhinovirus), adenovirus (Adenovirus), respiratory syncytial virus (Pneumovirus) and parainfluenza virus (Paramyxovirus)).
According to the mechanism of antiviral action, it belongs to fusion inhibitors (fusion), interacts with hemagglutinin of the virus and prevents the fusion of the lipid membrane of the virus and cell membranes.
It has a moderate immunomodulatory effect, increases the body's resistance to viral infections. It has interferon-inducing activity - in a study on mice, the induction of interferons was noted after 16 hours, and high titers of interferons persisted in the blood until 48 hours after administration.
Stimulates cellular and humoral immune responses: increases the number of lymphocytes in the blood, especially T cells (CD3), increases the number of T-helpers (CD4), without affecting the level of T-suppressors (CD8), normalizes immunoregulatory index, stimulates the phagocytic function of macrophages and increases the number of natural killers (NK-cells).
Therapeutic effectiveness in viral infections is manifested in reducing the duration and severity of the course of the disease and its main symptoms, as well as in reducing the incidence of complications associated with viral infection and exacerbations of chronic bacterial diseases.
Refers to low-toxic drugs (LD 50 >4 g/kg). Does not have any negative effect on the human body when administered orally at recommended doses.
Suction and distribution
Rapidly absorbed from the digestive tract. With max in the blood plasma is achieved after 1.5 hours.
Umifenovir is quickly distributed to the organs and tissues of the body.
Metabolism and excretion
Metabolized in the liver. T 1/2 is 17-21 hours.
About 40% is excreted unchanged, mainly with bile (38.9%) and in small quantities - kidneys (0.12%). During the first day, 90% of the dose is excreted.
Indications for use
- prevention and treatment in adults and children: influenza A and B, other SARS;
- complex therapy of acute intestinal infections of rotavirus etiology in children older than 6 years;
- complex therapy of chronic bronchitis, pneumonia and recurrent herpes infection;
- prevention of postoperative infectious complications.
- hypersensitivity to umifenoviru or any component of the drug;
- children up to 6 years of age;
- I trimester of pregnancy.
Dosage and administration
The drug is taken orally, before meals.
Single dose : children aged 6 to 12 years - 100 mg (1 capsule), for adults and children over 12 years of age - 200 mg (2 caps. 100 mg)
For non-specific prevention and treatment of influenza and other SARS in children and adults
During the epidemic of influenza and other SARS: children from 6 to 12 years - 100 mg, children over 12 years of age and adults - 200 mg 2 times a week for 3 weeks.
In direct contact with patients with influenza and other SARS - children 6 to 12 years - 100 mg, children over 12 years and adults - 200 mg 1 time / day for 10-14 days.
Treatment of influenza and other SARS
Children from 6 to 12 years- 100 mg, children over 12 years and adults- 200 mg 4 times / day (every 6 hours) for 5 days.
Complex therapy of acute intestinal infections of rotavirus etiology in children older than 6 years
Children from 6 to 12 years - 100 mg, children over 12 years - 200 mg 4 times / day (every 6 hours) for 5 days.
In the complex therapy of chronic bronchitis, pneumonia and recurrent herpes infection
Children from 6 to 12 years - 100 mg, children over 12 years and adults - 200 mg 4 times / day (every 6 hours) for 5-7 days, then a single dose of 2 times a week for 4 weeks.
Prevention of postoperative complications
Children from 6 to 12 years - 100 mg, children over 12 years old and adults - 200 mg 2 days before surgery, then 2 and 5 days after surgery.
Rarely: allergic reactions.
If these side effects are exacerbated, or any other side effects appear, the patient should inform the doctor about it.
The drug should be stored out of the reach of children at a temperature not higher than 25 ° C.
- Dosage form
- 100 mg
- Umifenevir hydrochloride
- Number of tablets
- INN Russian
- Умифеновира гидрохлорид
- Russian title