Progestogel 1%, gel for external use 80g, progesterone

Size chart
Women's clothing size
Euro 32/34 36 38 40
USA 0/2 4 6 8
Bust(in) 31-32 33 34 36
Bust(cm) 80.5-82.5 84.5 87 92
Waist(in) 24-25 26 27 29
Waist(cm) 62.5-64.5 66.5 69 74
Hips(in) 34-35 36 37 39
Hips(cm) 87.5-89.5 91.5 94 99
How To Measure Your Bust

With your arms relaxed at your sides, measure around the fullest part of your chest.

How To Measure Your Waist

Measure around the narrowest part of your natural waist, generally around the belly button. To ensure a comfortable fit, keep one finger between the measuring tape and your body.

Volume discounts

Quantity Unit discount You Save
2 16% $17.44
3 19% $31.07
4 22% $47.96
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Active ingredient

100 g of gel contains:

Active substance: natural micronized progesterone - 1 g;

Excipients: octyldodecanol, carbomer 980, macrogol glyceryl hydroxystearate (castor oil polyoxyl hydrogenogenated), trolamine (triethanolamine), ethanol in terms of absolute ethanol 96% (o / o), purified water.

Pharmacological properties

The active component of the drug is progesterone.

The action of progesterone is based on the blocking of estrogen receptors, as a result of which the absorption of fluid from tissues improves and the compression of the milky ducts decreases, as well as on the blocking of prolactin receptors in the breast tissue, which leads to a decrease in lactopoiesis.

Local use of the drug, creating a high concentration of progesterone in the area of application, does not have a systemic effect and avoids undesirable side effects.

The mechanism of action of Progestogel is based on an increase in the concentration of progesterone in the tissues of the mammary gland. Progesterone reduces the expression of estrogen receptors in breast tissue, and also reduces the local level of active estrogens by stimulating the production of enzymes (17-beta-hydroxysteroid dehydrogenase and estronsulfotransferase) that oxidize estradiol to less active estrone (binding the latter, enzymes turn it into inactive estrone sulfate).

Thus, progesterone limits the proliferative effect of estrogens on breast tissue.

Also, progesterone has a small natriodiuretic effect by inhibiting tubular reabsorption and increasing cellular filtration, preventing fluid retention during secretory transformations of the glandular component of the mammary glands and, as a result, the development of pain syndrome (mastalgia or mastodynia).

Along with this, the transdermal method of administration of progestogen also allows you to influence the state of the glandular epithelium and vascular network, as a result of which the permeability of capillaries decreases, the degree of swelling of breast tissue decreases, and the symptoms of mastalgia disappear.

Indications for use
Mastodynia (including those associated with taking oral contraceptives, pregnancy, puberty, premenopause, premenstrual tension syndrome, mastopathy).
Diffuse fibrocystic mastopathy.
  • nodular forms of fibrocystic mastopathy;
  • tumors (tumor-like formations) of the mammary glands of unclear etiology;
  • monotherapy of breast cancer;
  • monotherapy of genital cancer;
  • II and III trimesters of pregnancy;
  • individual hypersensitivity to the components of the drug.

With caution, the drug should be used for liver failure, renal failure, bronchial asthma, epilepsy, migraine, depression, hyperlipoproteinemia, ectopic pregnancy, abortion in the course, a tendency to thrombosis, in acute forms of phlebitis or thromboembolic diseases, bleeding of unclear etiology from the vagina; porphyria, arterial hypertension, diabetes mellitus.

Use in pregnancy and lactation

There is not enough experience with the use of the drug Prozhestogel ® during pregnancy.

The use of the drug during pregnancy and lactation is possible only when the intended benefit to the mother exceeds the potential risk to the fetus and child.

Use in case of impaired liver function
With caution, the drug should be used for liver failure.
Use in renal dysfunction
With caution, the drug should be used for renal failure.
Special instructions

Progestogel ® can be used for mastodynia associated with taking oral contraceptives, puberty, premenopause, premenstrual tension syndrome.

The drug should be applied to the skin of the mammary gland with an applicator-dispenser, without rubbing or massaging the mammary glands.

After applying the cream, direct sunlight should be avoided.

Influence on the ability to drive vehicles and mechanisms

Studies to identify the possible effect of the drug on the ability to drive a car or on the ability to control mechanisms not Were.

Dosage and Administration

1 application of the gel (2.5 g of gel; contains 0.025 g of progesterone) should be applied to the skin of the mammary glands with an applicator-dispenser until complete absorption 1-2 times / day daily or in the 2nd phase (from the 16th to the 25th day) of the menstrual cycle. The course of treatment is up to 3 cycles.

A second course of treatment can be prescribed only after consulting a doctor.

Due to low systemic absorption, overdose is unlikely.
Side effects

From the reproductive system: extremely rarely - soreness of the mammary glands, hot flushes, metrorrhagia, decreased libido.

Allergic reactions: erythema at the site of gel application, swelling of the lips and neck, fever, headache, nausea.

Storage conditions
The drug should be stored at a temperature not exceeding 25 ° C.
Shelf life - 2 years.
Keep out of reach of children.
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Product Details

Data sheet

Dosage form
INN Russian
Russian title
80 ml
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