L-Thyroxine 100 mcg tablets 100

$20.80
Size chart
Women's clothing size
SizeXSSML
Euro 32/34 36 38 40
USA 0/2 4 6 8
Bust(in) 31-32 33 34 36
Bust(cm) 80.5-82.5 84.5 87 92
Waist(in) 24-25 26 27 29
Waist(cm) 62.5-64.5 66.5 69 74
Hips(in) 34-35 36 37 39
Hips(cm) 87.5-89.5 91.5 94 99
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With your arms relaxed at your sides, measure around the fullest part of your chest.

How To Measure Your Waist

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Description
Country
Russia
Active ingredient
Levothyroxine sodium
Dosage

100 mcg

Composition

1 tablet contains: levothyroxine sodium - 100 mcg.

Pharmacological properties

Synthetic levorotatory isomer of thyroxine. After partial conversion to triiodothyronine (in the liver and kidneys) and transition to the cells of the body, it affects the development and growth of tissues, on metabolism.

In small doses, it has an anabolic effect on protein and fat metabolism. In medium doses, it stimulates growth and development, increases the need for tissues for oxygen, stimulates the metabolism of proteins, fats and carbohydrates, increases the functional activity of the cardiovascular system and the central nervous system.

In large doses inhibits the production of thyrotropin-releasing hormone hypothalamus and thyroid-stimulating pituitary hormone.

The therapeutic effect is observed after 7-12 days, during the same time the effect remains after discontinuation of the drug. The clinical effect of hypothyroidism is manifested after 3-5 days. Diffuse goiter decreases or disappears within 3-6 months.

Pharmacokinetics

When taken orally, levothyroxine sodium is absorbed almost exclusively in the upper part of the small intestine. Up to 80% of the dose of the drug is absorbed.

Food intake reduces the absorption of levothyroxine sodium. C max is achieved approximately 5-6 hours after ingestion. After absorption, more than 99% of the drug binds to serum proteins (thyroxine-binding globulin, thyroxine-binding prealbumin and albumin).

In various tissues, approximately 80% of levothyroxine sodium is monodeodized to form triiodothyronine (T) 3 ) and inactive products. Thyroid hormones are metabolized mainly in the liver, kidneys, brain and muscles.

A small amount of the drug is subjected to deamination and decarboxylation, as well as conjugation with sulfuric and glucuronic acids (in the liver).

Metabolites are excreted by the kidneys and through the intestines. The half-life of the drug is 6-7 days. With thyrotoxicosis, the half-life is shortened to 3-4 days, and with hypothyroidism, it lengthens to 9-10 days.

Indications for use
  • hypothyroidism;
  • euthyroid goiter;
  • as a replacement therapy and for the prevention of recurrence of goiter after resection of the thyroid gland;
  • thyroid cancer (after surgical treatment);
  • diffuse toxic goiter: after reaching a euthyroid state with thyrostatics (in the form of combined or monotherapy);
  • as a diagnostic means during the thyroid suppression test.
Contraindications
  • increased individual sensitivity to the drug;
  • untreated thyrotoxicosis;
  • acute myocardial infarction, acute myocarditis;
  • untreated adrenal insufficiency;
  • hereditary galactose intolerance, lactase deficiency or malabsorption of glucose and lactose.

With caution: the drug should be prescribed for diseases of the cardiovascular system: coronary heart disease (atherosclerosis, angina pectoris, myocardial infarction in the anamnesis), arterial hypertension, arrhythmia; with diabetes mellitus, severe long-existing hypothyroidism, malabsorption syndrome (dose adjustment may be required).

Dosage and Administration

The daily dose is determined individually depending on Readings.

L-thyroxine in a daily dose is taken orally in the morning on an empty stomach, at least 30 minutes before meals, washing down the tablet with a small amount of liquid (half a glass of water) and not chewing.

When conducting replacement therapy for hypothyroidism in patients younger than 55 years in the absence of cardiovascular diseases, L-thyroxine is prescribed in a daily dose of 1.6-1.8 μg / kg of body weight; in patients older than 55 years or with cardiovascular diseases - 0.9 μg / kg body weight. With severe obesity (BMI ≥ 30 kg / m 2 ) the calculation should be made on the "ideal weight".

The initial stage of replacement therapy for hypothyroidism
Patients without cardiovascular diseases younger than 55 years initial dose: women - 75-100 μg / day, men - 100-150 μg / day
Patients with cardiovascular diseases or older than 55 years initial dose – 25 mcg per day
increase by 25 μg with an interval of 2 months until the normalization of the TSH in the blood
When symptoms from the cardiovascular system appear or worsen, correct the therapy for cardiovascular diseases
Recommended doses of levothyroxine for the treatment of congenital hypothyroidism
Age Daily dose of levothyroxine (μg) Dose of levothyroxine based on body weight (μg/ kg)
0-6 months 25-50 10-15
6-12 months 50-75 6-8
1-5 years 75-100 5-6
6-12 years 100-150 4-5
≥12 years old 100-200 2-3
Testimony Recommended Doses
(L-thyroxine μg/day)
Treatment of euthyroid goiter 75-200
Prevention of relapse after surgical treatment of euthyroid goiter 75-200
In the complex therapy of thyrotoxicosis 50-100
Suppressive therapy for thyroid cancer 150-300
Thyroid suppression test 4 weeks before the test 3 weeks before the test 2 weeks before the test 1 week before the test
L-Thyroxine 75 μg/day 75 μg/day 150-200 μg/day 150-200 μg/day

Infants and children younger than 3 years of age are given a daily dose of L-thyroxine in one sitting 30 minutes before the first feeding. The tablet is dissolved in water to a thin suspension, which is prepared immediately before taking the drug.

In hypothyroidism, L-thyroxine is usually taken throughout life. In thyrotoxicosis, L-thyroxine is used in complex therapy with antithyroid agents after reaching a euthyroid state. In all cases, the duration of treatment with the drug is determined by the doctor.

Side effects

With the correct use of L-thyroxine under the supervision of a doctor, side effects are not observed.

With hypersensitivity to the drug, allergic reactions may be observed. The development of other side effects is due to an overdose of the drug.

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Product Details

Data sheet

Brand
Ozon
service_future
otc_02
Dosage form
Tablets
Dosage
100 mcg
INN
Levothyroxine sodium
Number of tablets
100
INN Russian
Левотироксин натрия
Russian title
L-Тироксин
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