Famotidine 40 mg tablets 20

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40 mg


Active ingredients: famotidine 0.04 g.

Excipients: lactose monohydrate, potato starch, croscarmellose sodium (primellose), silicon dioxide colloidal (azrosyl), magnesium stearate.

Pharmacological properties

Famotidine is a competitive histamine antagonist.

Acting on histamine H2 receptors of parietal cells, it significantly reduces the secretion of hydrochloric acid caused by various stimuli. Basal secretion of hydrochloric acid also decreases. To a lesser extent, the caused secretion of pepsinogen is inhibited. It causes dose-dependent suppression of hydrochloric acid production and a decrease in pepsin activity. Does not significantly change the level of gastrin in the plasma.

The duration of action of the drug with a single dose depends on the dose and ranges from 12 to 24 hours.

Indications for use
  • peptic ulcer of the stomach and duodenum, prevention of relapses;
  • erosive gastroduodenitis;
  • functional dyspepsia associated with increased secretory function;
  • symptomatic and stress ulcers of the gastrointestinal tract;
  • reflux esophagitis;
  • prevention of relapses associated with long-term use of NSAIDs;
  • Zollinger-Ellison syndrome;
  • systemic mastocytosis;
  • polyendocrine adenomatosis;
  • prevention of recurrence of bleeding in the postoperative period;
  • prevention of aspiration of gastric juice in patients who undergo operations under general anesthesia (Mendelssohn's syndrome);
  • prevention of aspiration pneumonitis;
  • dyspepsia with epigastric or retrosternal pain that occurs at night or is associated with food intake.
  • pregnancy;
  • lactation period;
  • children's age up to 3 years with a body weight of less than 20 kg (for this dosage form);
  • hypersensitivity to famotidine and other histamine H2 receptor blockers.

With caution: hepatic and / or renal failure, cirrhosis of the liver with portosystemic encephalopathy (in the anamnesis), immunodeficiency, children's age.

Dosage and Administration

Inside, without chewing, washed down with enough water.


With peptic ulcer of the stomach and 12-duodenal ulcer in the acute phase, symptomatic ulcers, erosive gastroduodenitis, 20 mg 2 times / day or 40 mg 1 time / day at night are usually prescribed. If necessary, the daily dose can be increased to 80-160 mg. The course of treatment is 4-8 weeks.

With dyspepsia associated with increased secretory function of the stomach, prescribe 20 mg 1-2 times / day.

In order to prevent relapses of peptic ulcer disease, 20 mg is prescribed 1 time / day before bedtime.

With reflux esophagitis - 20-40 mg 2 times / day for 6-12 weeks.

In Zollinger-Ellison syndrome, the dose of the drug and the duration of the course of treatment are set individually. The initial dose is usually 20 mg every 6 hours and can be increased to 160 mg every 6 hours.

To prevent aspiration of gastric juice with general anesthesia, 40 mg is prescribed in the evening and / or morning before surgery.

Famotidine tablets should be swallowed without chewing, washed down with a sufficient amount of water.

In renal failure, if the QC is less than 30 ml / min or the creatinine content in the blood serum is more than 3 mg / 100 ml, the daily dose of the drug should be reduced to 20 mg.

Children over 3 years old:

With peptic ulcer of the stomach and duodenum in the acute phase, reflux esophagitis Famotidine is prescribed to children with body weight more than 10 kg at the rate of 2 mg / kg / day, divided into 2 doses or 20 mg 2 times / day, but not more than 40 mg / day.

Side effects

From the digestive system: dry mouth, nausea, vomiting, abdominal pain, flatulence, constipation, diarrhea, appetite disturbance; increased activity of liver enzymes, hepatitis, acute pancreatitis.

From the side of the central nervous system: headache, dizziness, insomnia, anxiety, tinnitus; increased fatigue, drowsiness, depression, nervousness, psychosis; fuzziness of visual perception, paresis of accommodation; confusion, hallucinations, hyperthermia.

From the cardiovascular system: bradycardia, arrhythmia, vasculitis, decreased blood pressure, AV blockade.

Dermatological reactions: dry skin, alopecia, acne vulgaris, skin rash, itching, bronchospasm. antioneurotic edema, anaphylactic shock, other manifestations of hypersensitivity.

From the hematopoietic system: leukopenia, thrombocytopenia, agranulocytosis, pancytopenia, hypoplasia, bone marrow aplasia.

From the reproductive system: with prolonged use of large doses - hyperprolactinemia, gynecomastia, amenorrhea, decreased libido, impotence.

Other: fever, muscle pain, joint pain, increased levels of urea in the blood.

Storage conditions

Keep out of the reach of children, dry, out of light at a temperature of 15 ° to 25 ° C.

Shelf life - 3 years.

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Product Details

Data sheet

Dosage form
40 mg
Number of tablets
Russian title
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