Women's clothing size
Size | XS | S | M | L |
---|---|---|---|---|
Euro | 32/34 | 36 | 38 | 40 |
USA | 0/2 | 4 | 6 | 8 |
Bust(in) | 31-32 | 33 | 34 | 36 |
Bust(cm) | 80.5-82.5 | 84.5 | 87 | 92 |
Waist(in) | 24-25 | 26 | 27 | 29 |
Waist(cm) | 62.5-64.5 | 66.5 | 69 | 74 |
Hips(in) | 34-35 | 36 | 37 | 39 |
Hips(cm) | 87.5-89.5 | 91.5 | 94 | 99 |
With your arms relaxed at your sides, measure around the fullest part of your chest.
Measure around the narrowest part of your natural waist, generally around the belly button. To ensure a comfortable fit, keep one finger between the measuring tape and your body.
Country: Russia;
Trade name of the drug: Metoclopramide;
Dosage form: tablets;
Composition for one tablet
Metoclopramide hydrochloride monohydrate - 0.0105 g
(in terms of anhydrous) ... - 0.0100 g
Excipients:
lactose monohydrate (milk sugar) - 0.0660 g
potato starch .......... - 0.0200 g
calcium stearate ...................... - 0.0010 g
povidone-K30 ............................. - 0.0020 g
colloidal silicon dioxide (aerosil) - 0.0005 g
Description
Tablets from white to white with a yellowish or creamy shade,
flat-cylindrical, chamfered, with or without "R" marking on one side.
Pharmacotherapeutic group: antiemetic - dopamine receptors
central blocker.
ATX code: А03FA01
Pharmacological properties
Pharmacodynamics
Antiemetic, is a specific blocker of dopamine (D2) and
serotonin receptors. Has antiemetic effect, eliminates nausea and hiccups.
Reduces the motor activity of the esophagus, increases the tone of the lower esophageal sphincter,
speeds up the emptying of the stomach, and also speeds up the movement of food through the small intestine, not
causing diarrhea. Normalizes the secretion of bile, reduces the spasm of the sphincter of Oddi,
eliminates gallbladder dyskinesia. Stimulates the secretion of prolactin.
Pharmacokinetics
It is rapidly absorbed from the gastrointestinal tract. Bioavailability is 60-80%. Time
reaching the maximum concentration in blood plasma is 1-2 hours. Time
elimination half-life is from 3 to 5 hours, in case of impaired renal function - up to 14 hours.
the drug occurs mainly by the kidneys within 24 hours unchanged and in the form
conjugates. Passes through the placental and blood-brain barriers, enters
mother's milk.
Indications for use
• Vomiting, nausea, hiccups of various origins (in some cases it can be effective
with vomiting caused by radiation therapy or taking cytostatics);
• atony and hypotension of the stomach and intestines (in particular, postoperative);
• biliary dyskinesia;
• reflux esophagitis, flatulence, exacerbation of gastric ulcer and 12 duodenal ulcer
(as part of complex therapy);
• when carrying out X-ray contrast studies of the gastrointestinal tract (for
strengthening of peristalsis).
Contraindications
Hypersensitivity, gastrointestinal bleeding, pyloric stenosis
stomach, mechanical intestinal obstruction, perforation of the wall of the stomach or intestines,
pheochromocytoma, extrapyramidal disorders, epilepsy, prolactin-dependent tumors,
pregnancy, lactation, children under 18 years of age.
Carefully
Bronchial asthma, arterial hypertension, Parkinson's disease, renal and / or
liver failure, advanced age.
Application during pregnancy and during breastfeeding
The use of the drug in the first trimester of pregnancy is contraindicated. In II and III trimesters
the drug is used only in cases of emergency, if the potential benefit
to the mother outweighs the potential risk to the fetus.
If necessary, use of the drug during lactation should stop breastfeeding.
feeding for the entire period of treatment.
Method of administration and dosage
Inside. Adults - 10 mg 3-4 times a day 30 minutes before meals, the tablet is swallowed
whole and washed down with a little water. The maximum single dose is
20 mg, daily - 60 mg.
Side effect
From the nervous system: sometimes there may be a feeling of fatigue, headache,
dizziness, fear, anxiety, depression, drowsiness, tinnitus; v
in some cases, dyskinetic syndrome (involuntary
teak-like twitching of the muscles of the face, neck or shoulders). Possible appearance
extrapyramidal disorders: spasm of the facial muscles, trismus, rhythmic protrusion
tongue, bulbar type of speech, spasm of extraocular muscles (including oculogyric crisis),
spastic torticollis, opisthotonus, muscle hypertonicity. With long-term treatment in
some elderly patients may develop parkinsonism (tremor,
muscle twitching, limited mobility). In elderly patients with
chronic renal failure may also develop tardive dyskinesia. V
in isolated cases, the development of neuroleptic malignant syndrome is possible
(characteristic signs: fever, muscle contracture, altered consciousness and increased
blood pressure).
From the hematopoietic system: agranulocytosis.
From the cardiovascular system: supraventricular tachycardia, decreased or
increased blood pressure.
From the gastrointestinal tract: constipation, diarrhea, dry mouth.
From the endocrine system: with prolonged use of the drug in rare cases
gynecomastia (breast enlargement in men), galactorrhea may occur
(spontaneous flow of milk from the mammary glands), menstrual irregularities;
with the development of these phenomena, metoclopramide is canceled.
Overdose
Symptoms: Drowsiness, confusion, irritability, restlessness,
seizures, extrapyramidal movement disorders, dysfunction of the cardiovascular system with bradycardia, and a decrease or increase in blood pressure.
In mild forms of poisoning, the symptoms disappear 24 hours after the drug is discontinued. Depending on the severity of the symptoms, it is recommended to establish monitoring of vital
important functions of the patient. Overdose deaths are not
identified.
Treatment: symptomatic. Extrapyramidal disorders resolve slowly
the introduction of biperiden in a dose for adults 2.5-5 mg (biperiden is administered only under conditions
hospital, under the supervision of doctors). Diazepam can be used to calm the patient. At
ingestion of large doses of metoclopramide, gastric lavage is performed,
activated carbon and sodium sulfate.
Interaction with other medicinal products
The action of metoclopramide can be weakened by anticholinesterase drugs.
Metoclopramide enhances the absorption of antibiotics (tetracycline, ampicillin), paracetamol,
acetylsalicylic acid, levodopa, lithium preparations, ethanol; reduces absorption
digoxin and cimetidine; increases the concentration of bromocriptine in plasma. Enhances
the effect of alcohol and drugs that depress the central nervous system. Increases bioavailability
cyclosporine, which may require monitoring of its concentration. Not recommended
prescribe concurrently with antipsychotic drugs
(antipsychotics), as the risk of extrapyramidal reactions increases.
Use of metoclopramide in combination with serotonin reuptake inhibitors
can lead to increased development of extrapyramidal symptoms, including serotonin
syndrome.
special instructions
It is not recommended to consume ethanol during the treatment period.
If necessary, treatment with central anticholinergics and other
antiparkinsonian drugs.
Elderly patients taking the drug may develop tardive dyskinesia. Risk
the development of tardive dyskinesia depends on the duration of the course of pharmacotherapy and the total dose
drug. Irreversible changes develop, as a rule, when the drug is prescribed
more than 12 weeks. It is not recommended to prescribe the drug for more than 12 weeks, with the exception of
cases where the benefits of long-term use of the drug outweigh the potential risks
the development of an adverse reaction. When prescribing the drug in a short course and in low doses, also
development of tardive dyskinesia is possible, however, these changes usually disappear later
some time after discontinuation of the drug.
The ability to influence the reaction rate when driving or working with
other mechanisms
During the period of treatment, care must be taken when driving
means and engaging in other activities requiring increased concentration
attention and speed of psychomotor reactions.
Release form
10 mg tablets
Data sheet
- Brand
- Renewal
- service_future
- otc_00
- Dosage form
- Tablets
- Dosage
- 10 mg
- INN
- Metoclopramide
- INN Russian
- Метоклопрамид